Literature DB >> 4670432

Inhibitory effects of mitomycin-related compounds lacking the C1-C2 aziridine ring.

C M Mercado, M Tomasz.   

Abstract

Three chemical derivatives of mitomycin C cause loss of viability, inhibition of deoxyribonucleic acid synthesis, and inhibition of cell division in bacteria. Each of these drugs lacks the C(1)-C(2) aziridine ring previously postulated to be essential for the bactericidal effect of mitomycin C.

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Year:  1972        PMID： 4670432      PMCID： PMC444168          DOI： 10.1128/AAC.1.1.73

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  CHEMISTRY AND STRUCTURE OF MITOMYCIN C.

Authors:  C L STEVENS; K G TAYLOR; M E MUNK; W S MARSHALL; K NOLL; G D SHAH; L G SHAH; K UZU
Journal:  J Med Chem       Date:  1965-01       Impact factor: 7.446

2.  TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.

Authors:  J Spizizen
Journal:  Proc Natl Acad Sci U S A       Date:  1958-10-15       Impact factor: 11.205

3.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

4.  Model for the mechanism controlling the expression of competent state in Pneumococcus cultures.

Authors:  A Tomasz
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

5.  Mutants of Escherichia coli sensitive to antibiotics.

Authors:  H L Ennis
Journal:  J Bacteriol       Date:  1971-08       Impact factor: 3.490

6.  The biological studies on mitomycin I. Antibacterial activities of mitomycin derivatives.

Authors:  S Miyamura; N Shigeno; M Matsui; S Wakaki; K Uzu
Journal:  J Antibiot (Tokyo)       Date:  1967-03       Impact factor: 2.649

7.  The mitomycin antibiotics. Synthetic studies. XXI. Indoloquinone analogs with further variations at C-5.

Authors:  W A Remers; M J Weiss
Journal:  J Med Chem       Date:  1968-07       Impact factor: 7.446

8.  The mitomycin antibiotics. Synthetic studies. 18. Preparation of 1-(beta-substituted ethyl)indoloquinone analogs.

Authors:  G R Allen; M J Weiss
Journal:  J Med Chem       Date:  1967-01       Impact factor: 7.446

9.  Cell division in a species of Erwinia. V. Effect of metabolic inhibitors on terminal division and composition of a "division" medium.

Authors:  E A GRULA; M M GRULA
Journal:  J Bacteriol       Date:  1962-09       Impact factor: 3.490

10.  MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

Authors:  V N IYER; W SZYBALSKI
Journal:  Science       Date:  1964-07-03       Impact factor: 47.728
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