Literature DB >> 465481

Steady-state kinetics of mouse DNA polymerase beta.

K Tanabe, E W Bohn, S H Wilson.   

Abstract

DNA polymerase beta from mouse myeloma has been purified to near homogeneity, and its properties have been examined. The enzyme did not catalyze a detectable level of dNTP turnover, pyrophosphate exchange, pyrophosphorolysis, 3'-exonuclease degradation, or 5'-exonuclease degradation. Steady-state kinetic studies point to an ordered bibi mechanism for the polymerization reaction. Metal activation, which is required for polymerization, did not alter the Km for either the dNTP or the template--primer.

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Year:  1979        PMID： 465481     DOI： 10.1021/bi00582a029

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  28 in total

1.  Kinetic study of various binding modes between human DNA polymerase beta and different DNA substrates by surface-plasmon-resonance biosensor.

Authors:  Pui Yan Tsoi; Mengsu Yang
Journal:  Biochem J       Date:  2002-01-15       Impact factor: 3.857

2.  DNA replication defect in Salmonella typhimurium mutants lacking the editing (epsilon) subunit of DNA polymerase III.

Authors:  M R Lifsics; E D Lancy; R Maurer
Journal:  J Bacteriol       Date:  1992-11       Impact factor: 3.490

3.  DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota.

Authors:  Robert W Sobol
Journal:  DNA Repair (Amst)       Date:  2006-09-18

4.  A genetic system to identify DNA polymerase beta mutator mutants.

Authors:  S L Washington; M S Yoon; A M Chagovetz; S X Li; C A Clairmont; B D Preston; K A Eckert; J B Sweasy
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

5.  An abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity.

Authors:  Martin Klvaňa; Petr Jeřábek; Myron F Goodman; Jan Florián
Journal:  Biochemistry       Date:  2011-07-25       Impact factor: 3.162

Review 6.  Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.

Authors:  Sangwook Wu; William A Beard; Lee G Pedersen; Samuel H Wilson
Journal:  Chem Rev       Date:  2013-12-20       Impact factor: 60.622

7.  Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.

Authors:  Mariam M Mahmoud; Allison Schechter; Khadijeh S Alnajjar; Ji Huang; Jamie Towle-Weicksel; Brian E Eckenroth; Sylvie Doublié; Joann B Sweasy
Journal:  Biochemistry       Date:  2017-10-02       Impact factor: 3.162

8.  Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.

Authors:  J Horlacher; M Hottiger; V N Podust; U Hübscher; S A Benner
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

9.  Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions.

Authors:  Nelson L S Chan; Jinzhen Guo; Tianyi Zhang; Guogen Mao; Caixia Hou; Fenghua Yuan; Jian Huang; Yanbin Zhang; Jianxin Wu; Liya Gu; Guo-Min Li
Journal:  J Biol Chem       Date:  2013-04-12       Impact factor: 5.157

10.  Murine DNA polymerase beta gene: mapping of transcription initiation sites and the nucleotide sequence of the putative promoter region.

Authors:  M Yamaguchi; F Hirose; Y Hayashi; Y Nishimoto; A Matsukage
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272
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