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Literature DB >> 465377

Effects of tricresylphosphate on esterase activity of rat serum and tissues.

M Manno, F Rigoni, G B Bartolucci, M Bianchi, M Mazzotta.

Abstract

The effect of tricresylphosphate (TCP) was studied in vitro and in vivo on the rat liver and brain enzymes acetylcholinesterase (ACC), butyrylcholinesterase (CHE), arylesterase (ARE), aliesterase (ALI), and the microsomal nicotinamide-adenine dinucleotide phosphate oxidase (NADPH2-oxidase) system. The results show that, in the male rat, TCP given intraperitoneally induces an increase in liver microsomal ARE AND NADPH2-oxidase and a decrease in ALI and cholinesterase; no activation of ARE and NADPH2-oxidase is observed in female rats.

Entities: Chemical Gene Species

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Year: 1979 PMID： 465377 PMCID： PMC1008531 DOI： 10.1136/oem.36.2.153

Source DB: PubMed Journal: Br J Ind Med ISSN： 0007-1072

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References

9 in total

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Authors: T F Slater
Journal: Biochem J Date: 1968-01 Impact factor: 3.857

9 in total

Effects of tricresylphosphate on esterase activity of rat serum and tissues.

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9. The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride.