Literature DB >> 4651778

Enhancement of noradrenaline depletion in the cat spleen by phenoxybenzamine and phentolamine.

H Cripps, D P Dearnaley, P R Howe.   

Abstract

The noradrenaline content of the microsomal fraction of cat spleen was reduced by nerve stimulation. The reduction was greater in the presence of phenoxybenzamine and phentolamine, but was not affected by the presence of cocaine. The results suggest that phenoxybenzamine and phentolamine are able to increase the impulse-evoked release of noradrenaline.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 4651778      PMCID： PMC1666358          DOI： 10.1111/j.1476-5381.1972.tb06883.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Effect of drugs on the uptake and metabolism of H3-norepinephrine.

Authors:  G HERTING; J AXELROD; L G WHITBY
Journal:  J Pharmacol Exp Ther       Date:  1961-11       Impact factor: 4.030

2.  Facilitation of the release of noradrenaline and dopamine- -hydroxylase at low stimulation frequencies by -blocking agents.

Authors:  W P De Potter; I W Chubb; A Put; A F De Schaepdryver
Journal:  Arch Int Pharmacodyn Ther       Date:  1971-09

3.  Effect of nerve stimulation on the noradrenaline content of the spleen.

Authors:  D P Dearnaley; L B Geffen
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-12-13

4.  Antagonism between prostaglandin E2 and phenoxybenzamine on noradrenaline release from the cat spleen.

Authors:  P Hedqvist
Journal:  Acta Physiol Scand       Date:  1969-07

5.  Effect of phentolamine on noradrenaline uptake and release.

Authors:  K Starke; H Montel; J Wagner
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

6.  Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine.

Authors:  H Thoenen; A Hürlimann; W Haefely
Journal:  Experientia       Date:  1964-05-15

7.  The storage of endogenous noradrenaline in sympathetic nerve terminals.

Authors:  M A Bisby; M Fillenz
Journal:  J Physiol       Date:  1971-05       Impact factor: 5.182

8.  Enhanced release of dopamine- -hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins.

Authors:  D G Johnson; N B Thoa; R Weinshilboum; J Axelrod; I J Kopin
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205

9.  Effect of flow-stop on noradrenaline release from normal spleens and spleens treated with cocaine, phentolamine or phenoxybenzamine.

Authors:  S M Kirpekar; M Puig
Journal:  Br J Pharmacol       Date:  1971-10       Impact factor: 8.739

10.  Role of the -adrenoceptor in regulating noradrenaline overflow by nerve stimulation.

Authors:  M A Enero; S Z Langer; R P Rothlin; F J Stefano
Journal:  Br J Pharmacol       Date:  1972-04       Impact factor: 8.739
  10 in total
  3 in total

1.  An electrophysiological analysis of the effects of amine-uptake blockers and alpha-adrenoceptor blockers on adrenergic neuromuscular transmission.

Authors:  M R Bennett; J Middleton
Journal:  Br J Pharmacol       Date:  1975-09       Impact factor: 8.739

2.  Amphetamine and thermoregulation: studies in the unrestrained and curarized rat.

Authors:  A A Borbély; I R Baumann; P G Waser
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

3.  Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission.

Authors:  E S Vizi; G T Somogyi; P Hadházy; J Knoll
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.