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Literature DB >> 4651772

Effect of external lymph drainage and of coumarin treatment on thermal injury in the rat hind leg.

Abstract

1. External lymph drainage brings about a significant protective effect in thermal oedema of the rat hind leg. It is suggested that external lymph drainage prevents vasoactive substances drained from the site of injury from passing into the blood stream, which would further increase permeability of the injured blood capillaries.2. Coumarin (5,6-benzo-alpha-pyron) brings about a significant protective effect against the same injury in sham-operated rats.3. The strongest protective effect may be attained by combining external lymph drainage with the administration of coumarin.4. The additional therapeutic effect brought about by coumarin treatment in rats with external lymph drainage is not mediated by an increased flow. The possible mechanisms are discussed.

Entities: Chemical Disease Species

Mesh：

Substances：
Coumarins
Kinins
Proteins

Year: 1972 PMID： 4651772 PMCID： PMC1666345 DOI： 10.1111/j.1476-5381.1972.tb06870.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

10 in total

4. [Radiological study on the effect of drugs on lymphatic vessels of the legs. Possibilities of diagnostic use and therapeutic aspects].

Authors: M Collard
Journal: Fortschr Geb Rontgenstr Nuklearmed Date: 1971-11

7 in total

1. An in vitro demonstration of proteolysis by macrophages and its increase with coumarin.

Authors: T Bolton; J R Casley-Smith
Journal: Experientia Date: 1975-03-15

2. Fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin.

Authors: J R Casley-Smith; E Földi-Börcsök; M Földi
Journal: Br J Exp Pathol Date: 1974-02

3. Electron microscopy of the effects of histamine and thermal injury on the blood and lymphatic endothelium, and the mesothelium of the mouse's diaphragm, together with the influence of coumarin and rutin.

Authors: J R Casley-Smith; T Bolton
Journal: Experientia Date: 1973-11-15

Effect of external lymph drainage and of coumarin treatment on thermal injury in the rat hind leg.

1. KININ-FORMING ACTIVITY AND HISTAMINE IN LYMPH AFTER TISSUE INJURY.

2. [The effect of the Melilotus preparation Esberiven on the lymph flow].

3. Plasma-kinin-forming enzymes in body fluids and tissues.

4. [Radiological study on the effect of drugs on lymphatic vessels of the legs. Possibilities of diagnostic use and therapeutic aspects].

5. [Effect of coumarin from Melilotus officinalis on the function of the lymphatic vessel].

6. [The anti-inflammatory and anti-edematous effects of coumarins from Melilotus officinalis].

7. [Effect of Esberiven forte on lymph flow in the human thoracic duct].

8. Substrates for plasma kinin-forming enzymes in human, dog and rabbit plasmas.

9. Intracellular enzymes in local lymph as a measure of cellular injury.

10. Effect of thermal injury on the kinin system in rabbit hind limb lymph.

1. An in vitro demonstration of proteolysis by macrophages and its increase with coumarin.

2. Fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin.

3. Electron microscopy of the effects of histamine and thermal injury on the blood and lymphatic endothelium, and the mesothelium of the mouse's diaphragm, together with the influence of coumarin and rutin.

4. The ineffectiveness of coumarin treatment on thermal oedema of macrophage-free rats.

5. A comparison of the effectiveness of some anti-inflammatory drugs on thermal oedema.

6. The resolution of thermal oedema at various temperatures under coumarin treatment.

7. Combined coumarin and omental transfer treatments for canine proximal obstructive lymphoedema.