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Literature DB >> 464593

Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis.

Abstract

Miconazole at minimal fungitoxic concentrations inhibits ergosterol biosynthesis in sporidia of Ustilago maydis by interference with sterol C14 demethylation. The action is analogous to that of the fungicides triarimol and fenarimol. The fungicide 1-dodecylimidazole at low concentrations (0.1 to 0.25 mug/ml) inhibits sterol C14 demethylation; however, at higher concentrations (1.0 mug/ml or greater) it also inhibits 2,3-oxidosqualene cyclization and subsequent transmethylation. It is postulated that this diversity of effects of 1-dodecylimidazole results from binding of the inhibitor to sterol carrier protein(s).

Entities: Chemical Species

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Year: 1979 PMID： 464593 PMCID： PMC352718 DOI： 10.1128/AAC.15.4.603

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. THE SKIN STEROLS OF NORMAL AND TRIPARANOL-TREATED RATS.

Authors: R B CLAYTON; A N NELSON; I D FRANTZ
Journal: J Lipid Res Date: 1963-04 Impact factor: 5.922

2. A simple method for the isolation and purification of total lipides from animal tissues.

Authors: J FOLCH; M LEES; G H SLOANE STANLEY
Journal: J Biol Chem Date: 1957-05 Impact factor: 5.157

Review 3. Regulation of steroid biosynthesis.

Authors: M E Dempsey
Journal: Annu Rev Biochem Date: 1974 Impact factor: 23.643

4. Inhibition of ergosterol synthesis in Ustilago maydis by the fungicide triarimol.

Authors: N N Ragsdale; H D Sisler
Journal: Biochem Biophys Res Commun Date: 1972-03-24 Impact factor: 3.575

5. Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.

Authors: K H Sreedhara Swamy; M Sirsi; G R Ramananda Rao
Journal: Antimicrob Agents Chemother Date: 1974-04 Impact factor: 5.191

6. Specific effects of triarimol on sterol biosynthesis in Ustilago maydis.

Authors: N N Ragsdale
Journal: Biochim Biophys Acta Date: 1975-01-24

7. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent.

Authors: S D Atkin; B Morgan; K H Baggaley; J Green
Journal: Biochem J Date: 1972-11 Impact factor: 3.857

Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis.

1. THE SKIN STEROLS OF NORMAL AND TRIPARANOL-TREATED RATS.

2. A simple method for the isolation and purification of total lipides from animal tissues.

Review 3. Regulation of steroid biosynthesis.

4. Inhibition of ergosterol synthesis in Ustilago maydis by the fungicide triarimol.

5. Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.

6. Specific effects of triarimol on sterol biosynthesis in Ustilago maydis.

7. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent.

8. Cytochemical and biochemical studies of yeasts after in vitro exposure to miconazole.

9. The sterols of the echinoderm Asterias rubens.

10. Differential effects of cholesterol and lanosterol on artificial membranes.

1. Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.

2. Heterogeneity of action of mechanisms among antimycotic imidazoles.

3. Effect of ketoconazole and miconazole on skeletal muscle mitochondrial calcium transport system.

4. In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.

5. The squalene-2,3-epoxide cyclase as a model for the development of new drugs.