Literature DB >> 4639022

Hemoglobin Istanbul: substitution of glutamine for histidine in a proximal histidine (F8(92) ).

M Aksoy, S Erdem, G D Efremov, J B Wilson, T H Huisman, W A Schroeder, J R Shelton, J B Shelton, O N Ulitin, A Müftüoğlu.   

Abstract

A presumably spontaneous mutation has resulted in the formation of Hemoglobin (Hb) Istanbul in which glutamine is substituted for histidine in the proximal position of the beta-chain (F8(92)). The anemia and other physiological effects that occur in the presence of Hb Istanbul were much ameliorated by splenectomy. Hb Istanbul is a relatively unstable molecule which produces a rather moderate case of "unstable hemoglobin hemolytic anemia."In the determination of structure, a method of preferential cleavage of an aspartyl-proline bond at residues 99-100 of the beta-chain was used.

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Year:  1972        PMID： 4639022      PMCID： PMC292405          DOI： 10.1172/JCI107050

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  22 in total

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2.  Studies on the heterogeneity of hemoglobin. 13. Chromatography of various human and animal hemoglobin types on DEAE-Sephadex.

Authors:  A M Dozy; E F Kleihauer; T H Huisman
Journal:  J Chromatogr       Date:  1968-02-20

3.  An improved gradient for ion exchange chromatography of peptides on Dowex-1.

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4.  Studies on the heterogeneity of hemoglobin. IX. The use of Tris(hydroxymethyl)aminomethanehcl buffers in the anion-exchange chromatography of hemoglobins.

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5.  The amino acid sequence of the gamma chain of bovine fetal hemoglobin.

Authors:  D R Babin; W A Schroeder; J R Shelton; J B Shelton; B Robberson
Journal:  Biochemistry       Date:  1966-04       Impact factor: 3.162

6.  On the aminoethylation of proteins.

Authors:  M A Raftery; R D Cole
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7.  A simple method for the quantitation of haemoglobin-A2 by starch gel electrophoresis.

Authors:  M Aksoy; S Erdem
Journal:  Clin Chim Acta       Date:  1965-12       Impact factor: 3.786

8.  The gel-filtration behaviour of proteins related to their molecular weights over a wide range.

Authors:  P Andrews
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9.  Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok).

Authors:  J B Clegg; M A Naughton; D J Weatherball
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

10.  Estimation of the molecular weights of proteins by Sephadex gel-filtration.

Authors:  P Andrews
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.766
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  3 in total

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  3 in total

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