Literature DB >> 463688

Effect of ergometrine on contractile force of guinea-pig isolated heart: antagonism by cimetidine.

S Bongrani, M Di Donato, O Visioli, P Mantovani.   

Abstract

The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.

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Year:  1979        PMID： 463688     DOI： 10.1007/bf02024090

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Spontaneously and pharmacologically provoked coronary arterial spasm in Prinzmetal variant angina.

Authors:  C B Higgins; L Wexler; J F Silverman; W G Hayden; W L Anderson; J H Schroeder
Journal:  Radiology       Date:  1976-06       Impact factor: 11.105

Review 2.  Dopamine receptors: a review.

Authors:  G N Woodruff
Journal:  Comp Gen Pharmacol       Date:  1971-12

3.  Studies on the positive inotropic effect of dopamine in the guinea-pig heart.

Authors:  A Mugelli; F Ledda; L Mantelli; M Torrini; T Maccioni
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

4.  Identification of the smooth muscle excitatory receptors for ergot alkaloids.

Authors:  I R Innes
Journal:  Br J Pharmacol Chemother       Date:  1962-08

5.  The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.

Authors:  A Giotti; A Guidotti; P F Mannaioni; L Zilletti
Journal:  J Physiol       Date:  1966-06       Impact factor: 5.182

6.  The cardiovascular effects of ergometrine in the experimental animal in vivo and in vitro.

Authors:  M R Wassef; H Lal; B J Pleuvry
Journal:  Br J Anaesth       Date:  1974-07       Impact factor: 9.166
  6 in total
  1 in total

1.  Effects of vasoactive stimuli on coronary vascular resistance in isolated perfused rabbit hearts: no vasospastic response to ergonovine with or without atherogenic diet.

Authors:  T von Arnim; F Crea; S Chierchia; G R Thompson; A Maseri
Journal:  Basic Res Cardiol       Date:  1983 Jul-Aug       Impact factor: 17.165
  1 in total

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