Literature DB >> 4631920

Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.

E F Elslager, O D Bird, J Clarke, S C Perricone, D F Worth.   

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Year:  1972        PMID： 4631920     DOI： 10.1021/jm00281a012

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  5 in total

1.  Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Authors:  Alexis Nzila; Matthias Rottmann; Penchit Chitnumsub; Stevens M Kiara; Sumalee Kamchonwongpaisan; Cherdsak Maneeruttanarungroj; Supannee Taweechai; Bryan K S Yeung; Anne Goh; Suresh B Lakshminarayana; Bin Zou; Josephine Wong; Ngai Ling Ma; Margaret Weaver; Thomas H Keller; Veronique Dartois; Sergio Wittlin; Reto Brun; Yongyuth Yuthavong; Thierry T Diagana
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

2.  New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria.

Authors:  Lisa H Xie; Qigui Li; Ai J Lin; Kirsten Smith; Jing Zhang; Donald S Skillman
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

3.  Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors.

Authors:  J D Berman; M King; N Edwards
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

4.  Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats.

Authors:  Qigui Li; Michael P Kozar; Todd W Shearer; Lisa H Xie; Ai J Lin; Kirsten S Smith; Yuanzheng Si; Lalaine Anova; Jing Zhang; Wilbur K Milhous; Donald R Skillman
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

Review 5.  Prodrugs for the treatment of neglected diseases.

Authors:  Man Chin Chung; Elizabeth Igne Ferreira; Jean Leandro Santos; Jeanine Giarolla; Daniela Gonçales Rando; Adélia Emília Almeida; Priscila Longhin Bosquesi; Renato Farina Menegon; Lorena Blau
Journal:  Molecules       Date:  2007-03-19       Impact factor: 4.411
  5 in total

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