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Literature DB >> 4626405

Calcium-regulated parathyroid hormone peptidase.

J A Fischer, S B Oldham, G W Sizemore, C D Arnaud.

Abstract

An enzymatic activity that catalyzes the conversion of glandular parathyroid hormone to a smaller-molecular-weight, biologically and immunologically active form of this hormone has been extracted from normal parathyroid and other porcine tissues. The product of the conversion has the immunologic characteristics of the hormone that occurs in peripheral serum and in tissue culture medium from parathyroid explants. The enzyme is activated by chelating agents and is inhibited by high calcium concentrations, suggesting that this enzyme may be important in the regulation of secretion or metabolism of the hormone.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4626405 PMCID： PMC426930 DOI： 10.1073/pnas.69.8.2341

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Immunoassay of endogenous plasma insulin in man.

Authors: R S YALOW; S A BERSON
Journal: J Clin Invest Date: 1960-07 Impact factor: 14.808

2. Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors: W M HUNTER; F C GREENWOOD
Journal: Nature Date: 1962-05-05 Impact factor: 49.962

3. Iodoinsulin used to determine specific activity of iodine-131.

Authors: S A Berson; R S Yalow
Journal: Science Date: 1966-04-08 Impact factor: 47.728

4. Extraction, purification and partial characterization of porcine parathyroid hormone.

Authors: E T Littledike; C D Hawker
Journal: Endocrinology Date: 1967-08 Impact factor: 4.736

5. Glucagon clearance by the isolated perfused rat liver.

Authors: K D Buchanan; S S Solomon; J E Vance; H P Porter; R H Williams
Journal: Proc Soc Exp Biol Med Date: 1968-06

6. Immunochemical heterogeneity of parathyroid hormone in plasma.

Authors: S A Berson; R S Yalow
Journal: J Clin Endocrinol Metab Date: 1968-07 Impact factor: 5.958

7. The amino acid sequence of bovine parathyroid hormone I.

Authors: H D Niall; H Keutmann; R Sauer; M Hogan; B Dawson; G Aurbach; J Potts
Journal: Hoppe Seylers Z Physiol Chem Date: 1970-12

8. The metabolism of proinsulin and insulin by the liver.

Authors: A H Rubenstein; L A Pottenger; M Mako; G S Getz; D F Steiner
Journal: J Clin Invest Date: 1972-04 Impact factor: 14.808

9. Parathyroid hormone: secretion and metabolism in vivo.

Authors: J F Habener; D Powell; T M Murray; G P Mayer; J T Potts
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

10. Radioimmunoassay of human parathyroid hormone in serum.

Authors: C D Arnaud; H S Tsao; T Littledike
Journal: J Clin Invest Date: 1971-01 Impact factor: 14.808

15 in total

1. A possible autoimmune parathyroiditis following ozone inhalation. II. A histopathologic, ultrastructural, and immunofluorescent study.

Authors: O S Atwal; B S Samagh; M K Bhatnagar
Journal: Am J Pathol Date: 1975-07 Impact factor: 4.307

2. Metabolism of bovine parathyroid hormone. Immunological and biological characteristics of fragments generated by liver perfusion.

Authors: J M Canterbury; L A Bricker; G S Levey; P L Kozlovskis; E Ruiz; J E Zull; E Reiss
Journal: J Clin Invest Date: 1975-06 Impact factor: 14.808

3. Degradation of parathyroid hormone and fragment production by the isolated perfused dog kidney. The effect of glomerular filtration rate and perfusate CA++ concentrations.

Authors: K A Hruska; K Martin; P Mennes; A Greenwalt; C Anderson; S Klahr; E Slatopolsky
Journal: J Clin Invest Date: 1977-09 Impact factor: 14.808

Calcium-regulated parathyroid hormone peptidase.

1. Immunoassay of endogenous plasma insulin in man.

2. Preparation of iodine-131 labelled human growth hormone of high specific activity.

3. Iodoinsulin used to determine specific activity of iodine-131.

4. Extraction, purification and partial characterization of porcine parathyroid hormone.

5. Glucagon clearance by the isolated perfused rat liver.

6. Immunochemical heterogeneity of parathyroid hormone in plasma.

7. The amino acid sequence of bovine parathyroid hormone I.

8. The metabolism of proinsulin and insulin by the liver.

9. Parathyroid hormone: secretion and metabolism in vivo.

10. Radioimmunoassay of human parathyroid hormone in serum.

1. A possible autoimmune parathyroiditis following ozone inhalation. II. A histopathologic, ultrastructural, and immunofluorescent study.

2. Metabolism of bovine parathyroid hormone. Immunological and biological characteristics of fragments generated by liver perfusion.

3. Degradation of parathyroid hormone and fragment production by the isolated perfused dog kidney. The effect of glomerular filtration rate and perfusate CA++ concentrations.

4. Selective uptake of intact parathyroid hormone by the liver: differences between hepatic and renal uptake.

5. Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro.

6. Immunoheterogeneity of parathyroid hormone in venous effluent serum from hyperfunctioning parathyroid glands.

7. Activation of renal cortical adenylate cyclase by circulating immunoreactive parathyroid hormone fragments.

8. Heterogeneity of parathyroid hormone. Clinical and physiologic implications.

9. Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro.

10. The metabolism of labeled parathyroid hormone. V. Collected biological studies.