Literature DB >> 4624461

Chronic effects of osmotic opening of the blood-brain barrier in the monkey.

S I Rapoport, D S Bachman, H K Thompson.   

Abstract

In the monkey, the blood-brain barrier and the blood-aqueous and blood-vitreous barriers of the eye can be opened by internal carotid perfusion of solutions of 2 molar urea in a way compatible with survival and, in some few cases, without detectable neurological deficits. Urea presumably acts by osmotically shrinking the endothelial cells of the cerebrovascular vessels and opening their tight junctions. The high incidence of brain necrosis with neurological sequelae after perfusion of urea by the present technique precludes the use of osmotic opening of the blood-brain barrier for pharmacotherapy at this time.

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Year:  1972        PMID： 4624461     DOI： 10.1126/science.176.4040.1243

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation.

Authors:  Juyoung Park; Zhenzhen Fan; Ronald E Kumon; Mohamed E H El-Sayed; Cheri X Deng
Journal:  Ultrasound Med Biol       Date:  2010-07       Impact factor: 2.998

Review 2.  Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches.

Authors:  Niyanta N Kumar; Michelle E Pizzo; Geetika Nehra; Brynna Wilken-Resman; Sam Boroumand; Robert G Thorne
Journal:  Bioconjug Chem       Date:  2018-10-24       Impact factor: 4.774

3.  Structural changes in the rat brain after carotid infusions of hyperosmolar solutions. An electron microscopic study.

Authors:  T S Salahuddin; B B Johansson; H Kalimo; Y Olsson
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

Review 4.  Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions. An immunohistochemical study in the rat indicating longlasting changes in the brain microenvironment and multifocal nerve cell injuries.

Authors:  T S Salahuddin; H Kalimo; B B Johansson; Y Olsson
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

5.  Cellular basis of anoxic-ischemic brain injury.

Authors:  M M Bronshvag
Journal:  West J Med       Date:  1978-07

6.  Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier.

Authors:  E A Neuwelt; J A Barranger; R O Brady; M Pagel; F S Furbish; J M Quirk; G E Mook; E Frenkel
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

7.  Microvascular permeability in induced astrocytomas and peritumor neuropil of rat brain. A high-voltage electron microscope-protein tracer study.

Authors:  R R Shivers; C L Edmonds; R F Del Maestro
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

8.  Adenosine receptor agonist NECA increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.

Authors:  Chih-Chung Cheng; Ya Lan Yang; Kate Hsiurong Liao; Ted Weita Lai
Journal:  Sci Rep       Date:  2016-03-30       Impact factor: 4.379
  8 in total

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