Literature DB >> 4615977

Induction by mutagens of tandem gene duplications in the glyS region of the Escherichia coli chromosome.

D S Straus.   

Abstract

Four mutagens (ultraviolet light, nitrous acid, the acridine half mustard ICR 372, and niridazole) have been found to increase the frequency of tandem gene duplications in the glyS region of the Escherichia coli chromosome. This result was obtained by quantitating the spontaneous and mutagen-induced reversion frequency of a glycyl-tRNA synthetase (glyS) mutant. Following mutagenesis, as many as 0.2% of the survivors were observed to contain duplications in the glyS region. In addition, several classes of stable revertants of the glyS mutant have been identified.

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Year:  1974        PMID： 4615977      PMCID： PMC1224556     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  4 in total

1.  Duplication of the structural gene for glycyl-transfer RNA synthetase in Escherichia coli.

Authors:  W R Folk; P Berg
Journal:  J Mol Biol       Date:  1971-06-14       Impact factor: 5.469

2.  Instability of a missense suppressor resulting from a duplication of genetic material.

Authors:  C W Hill; J Foulds; L Soll; P Berg
Journal:  J Mol Biol       Date:  1969-02-14       Impact factor: 5.469

3.  Frameshift mutagenesis in Salmonella.

Authors:  B N Ames; H J Whitfield
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1966

Review 4.  Classification and mapping of spontaneous and induced mutations in the histidine operon of Salmonella.

Authors:  P E Hartman; Z Hartman; R C Stahl
Journal:  Adv Genet       Date:  1971       Impact factor: 1.944
  4 in total
  7 in total

1.  Genetic and segregation analysis of Escherichia coli strains containing a tandem duplication of the trpD-purB region of the chromosome.

Authors:  M H Simonian; R V Goldstein; R D Mosteller
Journal:  J Bacteriol       Date:  1978-02       Impact factor: 3.490

Review 2.  Extrachromosomal elements as possible agents of adaptation and development.

Authors:  D Reanney
Journal:  Bacteriol Rev       Date:  1976-09

3.  Induction of genetic duplications and frameshift mutations in Salmonella typhimurium by acridines and acridine mustards: dependence on covalent binding of the mutagen to DNA.

Authors:  G R Hoffmann; C S Freemer; L A Parente
Journal:  Mol Gen Genet       Date:  1989-09

4.  Lowered induction of genetic tandem duplications in Salmonella by the pKM101 plasmid.

Authors:  M L Pall; B J Hunter
Journal:  Mol Gen Genet       Date:  1986-08

5.  Tandem duplication induced by an unusual ampA1-, ampC-transducing lambda phage: a probe to initiate gene amplification.

Authors:  T Edlund; T Grundström; G R Björk; S Normark
Journal:  Mol Gen Genet       Date:  1980

6.  Duplications of histidine transport genes in Salmonella typhimurium and their use for the selection of deletion mutants.

Authors:  G F Ames; D P Biek; E N Spudich
Journal:  J Bacteriol       Date:  1978-12       Impact factor: 3.490

7.  Genetic instability associated with the aroC321 allele in Salmonella typhimurium involves genetic duplication.

Authors:  G R Hoffman; M J Walkowicz; J M Mason; J F Atkins
Journal:  Mol Gen Genet       Date:  1983
  7 in total

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