Literature DB >> 4612020

Regulation of synthesis of the branched-chain amino acids and cognate aminoacyl-transfer ribonucleic acid synthetases of Escherichia coli: a common regulatory element.

J Jackson, L S Williams, H E Umbarger.   

Abstract

Regulation of isoleucine, valine, and leucine biosynthesis and isoleucyl-, valyl-, and leucyl-transfer ribonucleic acid (tRNA) synthetase formation was examined in two mutant strains of Escherichia coli. One mutant was selected for growth resistance to the isoleucine analogue, ketomycin, and the other was selected for growth resistance to both trifluoroleucine and valine. Control of the synthesis of the branched-chain amino acids by repression was altered in both of these mutants. They also exhibited altered control of formation of isoleucyl-tRNA synthetase (EC 6.1.15, isoleucine:sRNA ligase, AMP), valyl-tRNA synthetase (EC 6.1.1.9, valine:sRNA ligase, AMP), and leucyl-tRNA synthetase (EC 6.1.1.4, leucine:sRNA ligase, AMP). These results suggest the existence of a common element for the control of these two classes of enzymes in Escherichia coli.

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Year:  1974        PMID： 4612020      PMCID： PMC245925          DOI： 10.1128/jb.120.3.1380-1386.1974

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  Use of chloramphenicol to study control of RNA synthesis in bacteria.

Authors:  D G FRAENKEL; F C NEIDHARDT
Journal:  Biochim Biophys Acta       Date:  1961-10-14

2.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

3.  Defective transamination, a mechanism for resistance to ketomycin in Escherichia coli.

Authors:  J H Jackson; H E Umbarger
Journal:  Antimicrob Agents Chemother       Date:  1973-04       Impact factor: 5.191

4.  On the role of isoleucyl-tRNA synthetase in multivalent repression.

Authors:  J M Blatt; H E Umbarger
Journal:  Biochem Genet       Date:  1972-04       Impact factor: 1.890

5.  Mutants of Salmonella typhimurium with an altered leucyl-transfer ribonucleic acid synthetase.

Authors:  R R Alexander; J M Calvo; M Freundlich
Journal:  J Bacteriol       Date:  1971-04       Impact factor: 3.490

6.  Purification and properties of beta-isopropylmalate dehydrogenase.

Authors:  S J Parsons; R O Burns
Journal:  J Biol Chem       Date:  1969-02-10       Impact factor: 5.157

7.  Modification of valyl tRNA synthetase by bacteriophage in Escherichia coli.

Authors:  M J Chrispeels; R F Boyd; L S Williams; F C Neidhardt
Journal:  J Mol Biol       Date:  1968-02-14       Impact factor: 5.469

8.  Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.

Authors:  E McGinnis; L S Williams
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490

9.  Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine.

Authors:  A Szentirmai; H E Umbarger
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

10.  Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.

Authors:  D F Silbert; G R Fink; B N Ames
Journal:  J Mol Biol       Date:  1966-12-28       Impact factor: 5.469
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  12 in total

1.  Regulation of branched-chain aminoacyl-transfer ribonucleic acid synthetases in an ilvDAC deletion strain of Escherichia coli K-12.

Authors:  W Coleman; E L Kline; C S Brown; L S Williams
Journal:  J Bacteriol       Date:  1975-03       Impact factor: 3.490

2.  Two control systems modulate the level of glutaminyl-tRNA synthetase in Escherichia coli.

Authors:  A Y Cheung; L Watson; D Söll
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490

3.  Sequence and structural similarities between the leucine-specific binding protein and leucyl-tRNA synthetase of Escherichia coli.

Authors:  R M Williamson; D L Oxender
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

4.  Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. V. Mutants with increased levels of valyl-transfer ribonucleic acid synthetase.

Authors:  M Baer; K B Low; D Söll
Journal:  J Bacteriol       Date:  1979-07       Impact factor: 3.490

5.  Synthesis and activities of branched-chain aminoacyl-tRNA synthetases in threonine deaminase mutants of Escherichia coli.

Authors:  A L Williams; S M Whitfield; L S Williams
Journal:  J Bacteriol       Date:  1978-04       Impact factor: 3.490

6.  Regulation of branched-chain amino acid transport in Escherichia coli.

Authors:  S C Quay; D L Oxender
Journal:  J Bacteriol       Date:  1976-09       Impact factor: 3.490

7.  Isolation and characterization of a new globomycin-resistant dnaE mutant of Escherichia coli.

Authors:  K Sakka; T Watanabe; R Beers; H C Wu
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490

8.  Role of transport systems in amino acid metabolism: leucine toxicity and the branched-chain amino acid transport systems.

Authors:  S C Quay; T E Dick; D L Oxender
Journal:  J Bacteriol       Date:  1977-03       Impact factor: 3.490

9.  Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid.

Authors:  A Cheung; S Morgan; K B Low; D Söll
Journal:  J Bacteriol       Date:  1979-07       Impact factor: 3.490

10.  Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid.

Authors:  J Hughes; G Mellows
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
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