Measles virus-specific IgG in cerebrospinal fluid in multiple sclerosis.

The prevalence of measles virus-specific IgG in cerebrospinal fluid (C.S.F.) of patients with multiple sclerosis (M.S.) has been compared with that in fluids from patients with other neurological diseases and from normal control subjects. The prevalence in the three groups was 58.1%, 24.1%, and 0% respectively. Fivefold concentration of the specimens increased the prevalence in the first two groups to 80.6% and 34.5% respectively, while measles IgG was not detected in any fluids of the normal control group, even after concentration.