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Literature DB >> 4607030

Restoration of cell-mediated immunity to animals blocked by a humoral response.

Abstract

The T cells which mediate delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) are blocked by a normal humoral response and cannot be made to function by further immunization. They can be rescued to some extent by treatment with immunopotentiating agents such as cyclophosphamide (CY) which suppresses the antibody response selectively, or by BCG which interferes with the action of serum blocking factors. These two agents together can restore cell-mediated immunity completely, but a further antigenic stimulus is needed to reestablish DTH in mice blocked by a long period of continuous exposure to SRBC.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4607030 PMCID： PMC2139620 DOI： 10.1084/jem.140.3.865

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

8 in total

1. Influence of dose and route of antigen injection on the immunological induction of T cells.

Authors: P H Lagrange; G B Mackaness; T E Miller
Journal: J Exp Med Date: 1974-03-01 Impact factor: 14.307

2. Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells.

Authors: T E Miller; G B Mackaness; P H Lagrange
Journal: J Natl Cancer Inst Date: 1973-11 Impact factor: 13.506

3. Immunopotentiation with BCG. I. Immune response to different strains and preparations.

Authors: G B Mackaness; D J Auclair; P H Lagrange
Journal: J Natl Cancer Inst Date: 1973-11 Impact factor: 13.506

4. Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide.

Authors: J L Turk; D Parker; L W Poulter
Journal: Immunology Date: 1972-10 Impact factor: 7.397

5. Tumour immunology; escape mechanisms.

Authors: E Klein
Journal: Ann Inst Pasteur (Paris) Date: 1972-04

6. Feedback inhibition of specifically sensitized lymphocytes.

Authors: G B Mackaness; P H Lagrange; T E Miller; T Ishibashi
Journal: J Exp Med Date: 1974-03-01 Impact factor: 14.307

7. Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.

Authors: P H Lagrange; G B Mackaness; T E Miller
Journal: J Exp Med Date: 1974-06-01 Impact factor: 14.307

8. The modifying effect of BCG on the immunological induction of T cells.

Authors: G B Mackaness; P H Lagrange; T Ishibashi
Journal: J Exp Med Date: 1974-06-01 Impact factor: 14.307

8 in total

6 in total

Review 1. Myopia.

Authors: Paul N Baird; Seang-Mei Saw; Carla Lanca; Jeremy A Guggenheim; Earl L Smith Iii; Xiangtian Zhou; Kyoko-Ohno Matsui; Pei-Chang Wu; Padmaja Sankaridurg; Audrey Chia; Mohamad Rosman; Ecosse L Lamoureux; Ryan Man; Mingguang He
Journal: Nat Rev Dis Primers Date: 2020-12-17 Impact factor: 52.329

Restoration of cell-mediated immunity to animals blocked by a humoral response.

1. Influence of dose and route of antigen injection on the immunological induction of T cells.

2. Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells.

3. Immunopotentiation with BCG. I. Immune response to different strains and preparations.

4. Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide.

5. Tumour immunology; escape mechanisms.

6. Feedback inhibition of specifically sensitized lymphocytes.

7. Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.

8. The modifying effect of BCG on the immunological induction of T cells.

Review 1. Myopia.

Review 2. Non-canonical B cell functions in transplantation.

3. Levamisole augments the cytotoxic T-cell response depending on the dose of drugs and antigen administered.

4. Isoantiserum-augmented development of lymphocyte-mediated cytotoxicity.

5. Pre-emption of human cell-mediated lympholysis by a suppressive mechanism activated in mixed lymphocyte cultures.

6. Induced immune destruction of long-surviving, H-2 incompatible kidney transplants in mice.