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Literature DB >> 4600266

The enzymatic release of O6-methylguanine and 3-methyladenine from DNA reacted with the carcinogen N-methyl-N-nitrosourea.

Abstract

Endonuclease II (deoxyribonucleate oligonucleotidohydrolase, EC 3.1.4.30) of Escherichia coli has been shown to break phosphodiester bonds in alkylated DNA and depurinated DNA. The hypothesis that depurination is a step in the mechanism of the reaction with alkylated DNA is supported by in vitro experiments with DNA reacted with N-methyl-N-nitrosourea. Endonuclease II releases O(6)-methylguanine and 3-methyladenine, but not 7-methylguanine, from DNA that has been methylated by the carcinogen N-methyl-N-nitrosourea.

Entities: Chemical Species

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Year: 1974 PMID： 4600266 PMCID： PMC388377 DOI： 10.1073/pnas.71.5.2022

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Deoxyribonucleic acid nucleases. I. The use of a new method to observe the kinetics of deoxyribonucleic acid degradation by deoxyribonuclease I, deoxyribonuclease II, and Escherichia coli endonuclease I.

Authors: E Melgar; D A Goldthwait
Journal: J Biol Chem Date: 1968-09-10 Impact factor: 5.157

2. The introduction of radioisotopes into RNA by methylation in vitro.

Authors: K D Smith; J L Armstrong; B J McCarthy
Journal: Biochim Biophys Acta Date: 1967-07-18

3. Endonuclease II of E. coli. I. Isolation and purification.

Authors: E C Friedberg; D A Goldthwait
Journal: Proc Natl Acad Sci U S A Date: 1969-03 Impact factor: 11.205

4. Endonuclease II of E. coli.

Authors: E C Friedberg; D A Goldthwait
Journal: Cold Spring Harb Symp Quant Biol Date: 1968

5. Inactivation and mutation of coliphage T2 by N-methyl-and N-ethyl-N-nitrosourea.

Authors: A Loveless; C L Hampton
Journal: Mutat Res Date: 1969 Jan-Feb Impact factor: 2.433

6. Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.

Authors: A Loveless
Journal: Nature Date: 1969-07-12 Impact factor: 49.962

7. Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid.

Authors: E C Friedberg; S M Hadi; D A Goldthwait
Journal: J Biol Chem Date: 1969-11-10 Impact factor: 5.157

8. Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.

Authors: P F Swann; P N Magee
Journal: Biochem J Date: 1968-11 Impact factor: 3.857

9. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

Authors: P D Lawley; C J Thatcher
Journal: Biochem J Date: 1970-02 Impact factor: 3.857

10. Repair of alkylation damage: stability of methyl groups in Bacillus subtilis treated with methyl methanesulfonate.

Authors: L Prakash; B Strauss
Journal: J Bacteriol Date: 1970-06 Impact factor: 3.490

34 in total

1. Detection of different types of damage in alkylated DNA by means of human corrective endonuclease (correndonuclease).

Authors: N J Duker; G W Teebor
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

2. Methyl methane sulfonate-sensitive mutant of Escherichia coli deficient in an endonuclease specific for apurinic sites in deoxyribonucleic acid.

Authors: S Ljungquist; T Lindahl; P Howard-Flanders
Journal: J Bacteriol Date: 1976-05 Impact factor: 3.490

3. Characterization of human enzymes specific for damaged DNA: resolution of endonuclease for irradiated DNA from an apparent N-glycosidase active on alkylated DNA.

Authors: T P Brent
Journal: Nucleic Acids Res Date: 1977-07 Impact factor: 16.971

The enzymatic release of O6-methylguanine and 3-methyladenine from DNA reacted with the carcinogen N-methyl-N-nitrosourea.

1. Deoxyribonucleic acid nucleases. I. The use of a new method to observe the kinetics of deoxyribonucleic acid degradation by deoxyribonuclease I, deoxyribonuclease II, and Escherichia coli endonuclease I.

2. The introduction of radioisotopes into RNA by methylation in vitro.

3. Endonuclease II of E. coli. I. Isolation and purification.

4. Endonuclease II of E. coli.

5. Inactivation and mutation of coliphage T2 by N-methyl-and N-ethyl-N-nitrosourea.

6. Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.

7. Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid.

8. Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.

9. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

10. Repair of alkylation damage: stability of methyl groups in Bacillus subtilis treated with methyl methanesulfonate.

1. Detection of different types of damage in alkylated DNA by means of human corrective endonuclease (correndonuclease).

2. Methyl methane sulfonate-sensitive mutant of Escherichia coli deficient in an endonuclease specific for apurinic sites in deoxyribonucleic acid.

3. Characterization of human enzymes specific for damaged DNA: resolution of endonuclease for irradiated DNA from an apparent N-glycosidase active on alkylated DNA.

4. Apurinic endonucleases from Saccharomyces cerevisiae.

5. Escherichia coli gene that controls sensitivity to alkylating agents.

6. Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents.

7. Enzymatic insertion of purine bases into depurinated DNA in vitro.

8. Mechanisms of bacterial mutagenesis and properties of mutagenesis tester strains.

9. The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli.

10. Genetic evidence for the nature, and excision repair, of DNA lesions resulting from incorporation of 5-bromouracil.