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Literature DB >> 4599253

Genetic analysis of the active sites of lac repressor.

Abstract

Selection methods for the isolation of i(-d) and i(s) mutants are described. Two hundred and forty-seven i(-d) and 98 i(s) mutations have been localized by deletion mapping. All i(-d) mutations map in the region of the i gene, which codes for the aminoterminal part of the lac repressor, whereas i(s) mutations map in the middle of the i gene and at the proximal end of the i(-d) cluster.

Mesh：

Substances：

Year: 1974 PMID： 4599253 PMCID： PMC1213095

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

7 in total

1. Isolation of the lac repressor.

Authors: W Gilbert; B Müller-Hill
Journal: Proc Natl Acad Sci U S A Date: 1966-12 Impact factor: 11.205

2. Genetic map of the lactose repressor gene (i) of Escherichia coli.

Authors: M Pfahl
Journal: Genetics Date: 1972-11 Impact factor: 4.562

3. The amino-acid sequence of lac repressor.

Authors: K Beyreuther; K Adler; N Geisler; A Klemm
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

4. How lac repressor binds to DNA.

Authors: K Adler; K Beyreuther; E Fanning; N Geisler; B Gronenborn; A Klemm; B Müller-Hill; M Pfahl; A Schmitz
Journal: Nature Date: 1972-06-09 Impact factor: 49.962

5. Lac repressor-operator interaction. V. Characterization of super- and pseudo-wild-type repressors.

Authors: A Jobe; A D Riggs; S Bourgeois
Journal: J Mol Biol Date: 1972-02-28 Impact factor: 5.469

6. Direction of transcription of a regulatory gene in E. coli.

Authors: J H Miller; J Beckwith; B Muller-Hill
Journal: Nature Date: 1968-12-28 Impact factor: 49.962

7. Mutants that make more lac repressor.

Authors: B Müller-Hill; L Crapo; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1968-04 Impact factor: 11.205

7 in total

16 in total

1. Tight-binding repressors of the lac operon: selection system and in vitro analysis.

Authors: M Pfahl
Journal: J Bacteriol Date: 1979-01 Impact factor: 3.490

2. LambdacI mutants: intragenic complementation and complementation with a cI promoter mutant.

Authors: M Lieb
Journal: Mol Gen Genet Date: 1976-08-02

3. Biochemical-genetic study of the first enzyme of histidine biosynthesis in Salmonella typhimurium: substrate and feedback binding regions.

Authors: V J Wainscott; J J Ferretti
Journal: J Bacteriol Date: 1978-01 Impact factor: 3.490

Review 4. Genetic regulation of penicillinase synthesis in Gram-positive bacteria.

Authors: J Imsande
Journal: Microbiol Rev Date: 1978-03

5. Pseudoreversion of lactose operator-constitutive mutants.

Authors: W I Norwood; J R Sadler
Journal: J Bacteriol Date: 1977-04 Impact factor: 3.490

6. Composition of the first enzyme of histidine biosynthesis isolated from wild-type and mutant operator strains of Salmonella typhimurium.

Authors: S M Parsons; M Lipsky
Journal: J Bacteriol Date: 1975-02 Impact factor: 3.490