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Literature DB >> 4597731

Studies on the action of nalidixic acid in the yeast Saccharomyces cerevisiae.

C A Michaels, J Blamire, B Goldfinger, J Marmur.

Abstract

The effect of the antibiotic nalidixic acid on macromolecular metabolism in the yeast Saccharomyces cerevisiae has been studied. It was found that, upon the addition of nalidixic acid to a logarithmically growing culture, there is a transient inhibition of total cell ribonucleic acid, deoxyribonucleic acid, and protein synthesis, after which the cells show an almost complete recovery. In addition, there is no preferential inhibition of yeast mitochondrial deoxyribonucleic acid synthesis.

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Year: 1973 PMID： 4597731 PMCID： PMC444458 DOI： 10.1128/AAC.3.5.562

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. Nalidixic acid prevents the induction of yeast cytoplasmic respiration-deficient mutants by intercalating drugs.

Authors: M Vidová; L Kovác
Journal: FEBS Lett Date: 1972-05-15 Impact factor: 4.124

2. Conditions that prevent rho - -induction by ethidium bromide.

Authors: C P Hollenberg; P Borst
Journal: Biochem Biophys Res Commun Date: 1971-12-03 Impact factor: 3.575

3. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation.

Authors: L H Hartwell
Journal: J Mol Biol Date: 1971-07-14 Impact factor: 5.469

4. Mechanism of action of nalidixic acid on Escherichia coli. IV. Effects on the stability of cellular constituents.

Authors: T M Cook; W H Deitz; W A Goss
Journal: J Bacteriol Date: 1966-02 Impact factor: 3.490

5. The action of nalidixic acid on euglena plastids.

Authors: L Ebringer
Journal: J Gen Microbiol Date: 1970-04

6. Biosynthesis of yeast mitochondria. Drug effects on the petite negative yeast kluyveromyces lactis.

Authors: A A Luha; L E Sarcoe; P A Whittaker
Journal: Biochem Biophys Res Commun Date: 1971-07-16 Impact factor: 3.575

7. Effect of putative deoxyribonucleic acid inhibitors on macromolecular synthesis in Saccharomyces cerevisiae.

Authors: C T Wehr; R D Kudrna; L W Parks
Journal: J Bacteriol Date: 1970-06 Impact factor: 3.490

8. Bactericidal action of nalidixic acid on Bacillus subtilis.

Authors: T M Cook; K G Brown; J V Boyle; W A Goss
Journal: J Bacteriol Date: 1966-11 Impact factor: 3.490

9. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

Authors: W A GOSS; W H DEITZ; T M COOK
Journal: J Bacteriol Date: 1965-04 Impact factor: 3.490

10. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.

Authors: W A GOSS; W H DEITZ; T M COOK
Journal: J Bacteriol Date: 1964-10 Impact factor: 3.490

5 in total

1. Nalidixic acid and macromolecular metabolism in Tetrahymena pyriformis: effects on protein synthesis.

Authors: J F de Castro; J F Carvalho; N Moussatché; F T de Castro
Journal: Antimicrob Agents Chemother Date: 1975-05 Impact factor: 5.191

2. Mitochondrial DNA in yeast recombination and subsequent modification following mating between a Grande and a suppressive Petite.

Authors: J Blamire; C A Michels; J M Walsh; D L Friedenberg
Journal: Mol Gen Genet Date: 1976-02-02