Literature DB >> 459717

The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes.

B J Holub, J Piekarski.   

Abstract

The conversion of 2-acyl-sn-glycero-3-phosphorylinositol into phosphatidylinositol via acyl-CoA: 2-acyl-sn-glycero-3-phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl-CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1-position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl-CoA:2-acyl-sn-glycero-3-phosphorylcholine acyltransferase under certain assay conditions.

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Year:  1979        PMID： 459717     DOI： 10.1007/bf02533526

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  10 in total

1.  METABOLISM OF GLYCEROLIPIDS. VI. SPECIFICITIES OF ACYL COENZYME A: PHOSPHOLIPID ACYLTRANSFERASES.

Authors:  W E LANDS; P HART
Journal:  J Biol Chem       Date:  1965-05       Impact factor: 5.157

2.  The enzymatic synthesis of inositol monophosphatide.

Authors:  H PAULUS; E P KENNEDY
Journal:  J Biol Chem       Date:  1960-05       Impact factor: 5.157

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Synthesis of molecular classes of cytidine diphosphate diglyceride by rat liver in vivo and in vitro.

Authors:  W Thompson; G MacDonald
Journal:  Can J Biochem       Date:  1977-11

5.  Selective acylation of 1-acylglycerophosphorylinositol by rat brain microsomes. Comparison with 1-acylglycerophosphorylcholine.

Authors:  R R Baker; W Thompson
Journal:  J Biol Chem       Date:  1973-10-25       Impact factor: 5.157

6.  Structural and metabolic interrelationships among glycerophosphatides of rat liver in vivo.

Authors:  B J Holub; A Kuksis
Journal:  Can J Biochem       Date:  1971-12

7.  The Mn2+-activated incorporation of inositol into molecular species of phosphatidylinositol in rat liver microsomes.

Authors:  B J Holub
Journal:  Biochim Biophys Acta       Date:  1974-10-16

8.  Structural analyses of rat liver phosphoglycerides.

Authors:  R Wood; R D Harlow
Journal:  Arch Biochem Biophys       Date:  1969-12       Impact factor: 4.013

9.  Specific formation of arachidonoyl phosphatidylinositol from 1-acyl-sn-glycero-3-phosphorylinositol in rat liver.

Authors:  B J Holub
Journal:  Lipids       Date:  1976-01       Impact factor: 1.880

10.  Regulation of selectivity of CDPcholine: 1,2-diacyl-sn-glycerol cholinephosphotransferase in rat liver microsomes towards different molecular species of 1,2-diacyl-sn-glycerols.

Authors:  B J Holub
Journal:  Can J Biochem       Date:  1977-07
  10 in total
  4 in total

1.  LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice.

Authors:  Rieko Imae; Takao Inoue; Yasuko Nakasaki; Yasunori Uchida; Yohsuke Ohba; Nozomu Kono; Hiroki Nakanishi; Takehiko Sasaki; Shohei Mitani; Hiroyuki Arai
Journal:  J Lipid Res       Date:  2011-12-14       Impact factor: 5.922

2.  Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.

Authors:  Rieko Imae; Takao Inoue; Masako Kimura; Takahiro Kanamori; Naoko H Tomioka; Eriko Kage-Nakadai; Shohei Mitani; Hiroyuki Arai
Journal:  Mol Biol Cell       Date:  2010-07-28       Impact factor: 4.138

3.  On the specificity of a phospholipase A2 purified from the 106,000 X g pellet of bovine brain.

Authors:  N C Gray; K P Strickland
Journal:  Lipids       Date:  1982-02       Impact factor: 1.880

4.  Stereoselective effects of lysophosphatidylserine in rodents.

Authors:  H W Chang; K Inoue; A Bruni; E Boarato; G Toffano
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739
  4 in total

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