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Literature DB >> 4596652

Glomerular fibrinolytic activity following endotoxin-induced glomerular fibrin deposition in the pregnant rat.

Abstract

The effect of endotoxin on glomerular fibrinolysis in pregnant and nonpregnant rats was studied using a fibrin slide technic. Glomerular fibrinolytic activity was present and light microscopy was normal following endotoxin or saline injection in nonpregnant rats. In pregnant rats, fibrin was regularly detected within glomerular capillaries 2 hours following administration of endotoxin but was completely removed within 48 hours. Glomerular fibrinolytic activity was present throughout this time interval. These studies suggest that glomerular fibrinolytic activity plays an important role in the removal of glomerular fibrin.

Entities: Chemical Species

Mesh：

Substances：
Endotoxins
Fibrin

Year: 1974 PMID： 4596652 PMCID： PMC1910814

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

17 in total

1. PRODUCTION OF THE GENERALIZED SHWARTZMAN REACTION IN PREGNANT RATS BY INTRAVENOUS INFUSION OF THROMBIN.

Authors: W MARGARETTEN; H O ZUNKER; D G MCKAY
Journal: Lab Invest Date: 1964-06 Impact factor: 5.662

2. STUDIES ON THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION. II. ROLE PLAYED BY EXPERIMENTALLY INDUCED FIBRINOLYSIS.

Authors: F RODRIGUEZ ERDMANN
Journal: Thromb Diath Haemorrh Date: 1964-12-31

4. Accelerated serum sickness in the rabbit. II. Glomerular ultrastructural lesions in transient proliferative and progressive disorganizing glomerulonephritis.

Authors: H Shigematsu; Y Kobayashi
Journal: Virchows Arch A Pathol Anat Histol Date: 1976-03-05

5. Urinary plasminogen activator activity in progressive renal failure.

Authors: S Y Hong; D H Yang
Journal: Korean J Intern Med Date: 1990-01 Impact factor: 2.884

5 in total

Glomerular fibrinolytic activity following endotoxin-induced glomerular fibrin deposition in the pregnant rat.

1. PRODUCTION OF THE GENERALIZED SHWARTZMAN REACTION IN PREGNANT RATS BY INTRAVENOUS INFUSION OF THROMBIN.

2. STUDIES ON THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION. II. ROLE PLAYED BY EXPERIMENTALLY INDUCED FIBRINOLYSIS.

3. A study on the generalized Shwartzman reaction in pregnant rats induced by bacterial endotoxin.

4. The prevention of the generalized Shwartzman reaction by fibrinolytic activity.

5. The role of pregnancy in the induction of the generalized Shwartzman reaction.

6. Cortical fibrinolytic activity in normal and diseased human kidneys.

7. Fibrinolytic treatment of the haemolytic-uraemic syndrome.

8. Kidney tissue activator of fibrinolysis in relation to pregnancy.

9. Acute poststreptococcal glomerulonephritis: immune deposit disease.

10. An electron microscope study of the effects of bacterial endotoxin on the blood-vascular system.

Review 1. Glomerular fibrin deposition and removal.

2. Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

3. Cutaneous vascular fibrinolytic activity in the local Shwartzman reaction.

4. Accelerated serum sickness in the rabbit. II. Glomerular ultrastructural lesions in transient proliferative and progressive disorganizing glomerulonephritis.

5. Urinary plasminogen activator activity in progressive renal failure.