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Literature DB >> 4591179

Inhibition of a T-cell-dependent immune response in vitro by thymoma cell immunoglobulin.

J W Stocker, J J Marchalonis, A W Harris.

Abstract

Concentrated medium obtained from cultures of a continuous thymus-derived mouse lymphoma cell line (WEHI-22.1) was found to inhibit a T-cell-dependent (antidonkey red blood cell), but not a T-cell-independent (anti-DNP) immune response in vitro. Passage of such a concentrate through an anti-mouse Ig immunoadsorbent column removed its inhibitory activity. It is suggested that the tumor cell Ig can compete with specific normal T-cell Ig in its collaborative function in immune responses. A similar mechanism may account for anergy associated with some human lymphoid neoplasms.

Entities: CellLine Disease Species

Mesh：

Substances：
Antigen-Antibody Complex

Year: 1974 PMID： 4591179 PMCID： PMC2139540 DOI： 10.1084/jem.139.3.785

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

1. Zone electrophoresis.

Authors: H G KUNKEL
Journal: Methods Biochem Anal Date: 1954

2. Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

Authors: M Feldmann
Journal: Eur J Immunol Date: 1972-04 Impact factor: 5.532

3. Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

Authors: M Feldmann
Journal: J Exp Med Date: 1972-10-01 Impact factor: 14.307

4. Antibody-agarose immunoadsorbents: complete removal of classes of immunoglobulins from serum.

Authors: M Mannik; D E Stage
Journal: J Immunol Date: 1971-06 Impact factor: 5.422

5. Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

Authors: M Feldmann
Journal: Nat New Biol Date: 1971-05-05

6. Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor for antibody on cells of a thymoma cell line.

Authors: A W Harris; A D Bankhurst; S Mason; N L Warner
Journal: J Immunol Date: 1973-02 Impact factor: 5.422

Inhibition of a T-cell-dependent immune response in vitro by thymoma cell immunoglobulin.

1. Zone electrophoresis.

2. Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

3. Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

4. Antibody-agarose immunoadsorbents: complete removal of classes of immunoglobulins from serum.

5. Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

6. Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor for antibody on cells of a thymoma cell line.

7. Further improvements in the plaque technique for detecting single antibody-forming cells.

8. Mouse myelomas and lymphomas in culture.

9. Isolation and partial characterization of lymphocyte surface immunoglobulins.

10. Immunological tolerance in vitro: kinetic studies at the cellular level.

1. Surface immunoglobulin on cultured foetal mouse thymocytes.

2. Mouse T-cell tumour immunoglobulin. I. Antigenic properties and effects on T-cell responses.

3. Suppression of in vitro antibody synthesis by immunoglobulin-binding factor.