Literature DB >> 4584708

Influence of selection of patients on results of clinical trials.

J P Leff.   

Abstract

The hypothesis is advanced that any population of patients can be divided into those with a good prognosis, a poor prognosis, and an intermediate prognosis in respect to a particular treatment. The outcome of a clinical trial of treatment will be partly determined by the proportion of patients selected for the trial from each of these prognostic groups. The implications of the hypothesis are illustrated by consideration of three recent trials of treatment for psychiatric patients.

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Year:  1973        PMID: 4584708      PMCID: PMC1587193          DOI: 10.1136/bmj.4.5885.156

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  3 in total

1.  An evaluation of continuation therapy with tricyclic antidepressants in depressive illness.

Authors:  R H Mindham; C Howland; M Shepherd
Journal:  Psychol Med       Date:  1973-02       Impact factor: 7.723

2.  Continuation therapy with tricyclic antidepressants in depressive illness.

Authors:  R H Mindham; C Howland; M Shepherd
Journal:  Lancet       Date:  1972-10-21       Impact factor: 79.321

3.  Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: double-blind placebo trial. Report to the Medical Research Council Committee on Clinical Trials in Psychiatry.

Authors:  S R Hirsch; R Gaind; P D Rohde; B C Stevens; J K Wing
Journal:  Br Med J       Date:  1973-03-17
  3 in total
  4 in total

1.  Assessment of drugs in schizophrenia. Basic trial design.

Authors:  M Lader
Journal:  Br J Clin Pharmacol       Date:  1976-06       Impact factor: 4.335

2.  The ethics of clinical trials.

Authors:  J K Wing
Journal:  J Med Ethics       Date:  1975-12       Impact factor: 2.903

3.  Logic and inference in clinical trials.

Authors:  D W Vere
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335

Review 4.  Trifluoperazine versus placebo for schizophrenia.

Authors:  Kai Koch; Kamel Mansi; Euan Haynes; Clive E Adams; Stephanie Sampson; Vivek A Furtado
Journal:  Cochrane Database Syst Rev       Date:  2014-01-11
  4 in total

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