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Literature DB >> 4583888

Effect of a gene-specific suppressor mutation (das) on DNA synthesis of gene 46-47 mutants of bacteriophage T4D.

Abstract

Mutants in genes 46 and 47 of bacteriophage T4 exhibit early cessation of DNA synthesis, inability to form a normal rapidly sedimenting DNA intermediate (200S), reduced genetic recombination, and reduced viable phage production. A gene-specific suppressor mutation called das partially restores many of the pleiotropic effects of gene 46-47 mutants (13). Our results indicate that this partial suppression by das is associated with (i) the synthesis of a small fraction of DNA containing long single chains not detectable in 46-47 infection and (ii) a decrease in an "early" function which participates in the degradation of DNA synthesized in the absence of 46-47 functions. However, das does not restore the formation of a normal rapidly sedimenting (200S) DNA intermediate.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4583888 PMCID： PMC356627

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

18 in total

1. Degradation of cytosin-containing bacterial and bacteriophage DNA after infection of Escherichia coli B with bacteriophage T4D wild type and with mutants defective in genes 46, 47 and 56.

Authors: E M Kutter; J S Wiberg
Journal: J Mol Biol Date: 1968-12 Impact factor: 5.469

3. Membrane-associated DNase activity controlled by genes 46 and 47 of bacteriophage T4D and elevated DNase activity associated with the T4 das mutation.

Authors: C Mickelson; J S Wiberg
Journal: J Virol Date: 1981-10 Impact factor: 5.103

3 in total

Effect of a gene-specific suppressor mutation (das) on DNA synthesis of gene 46-47 mutants of bacteriophage T4D.

1. Degradation of cytosin-containing bacterial and bacteriophage DNA after infection of Escherichia coli B with bacteriophage T4D wild type and with mutants defective in genes 46, 47 and 56.

2. Transcription during bacteriophage T4 development: requirements for late messenger synthesis.

3. Mutants of bacteriophage T4 unable to cause breakdown of host DNA.

4. Variations in genetic recombination due to amber mutations in T4D bacteriophage.

5. Evidence for long DNA strands in the replicating pool after T4 infection.

6. Repair and recombination in phage T4. I. Genes affecting recombination.

7. Studies on the nature of the replicating DNA in Escherichia coli infected with certain amber mutants of phage T4.

8. The absence of mature phage DNA molecules from the replicating pool of T-even-infected Escherichia coli.

9. Studies on the nature of replicating DNA in T4-infected Escherichia coli.

10. Early intracellular events in the replication of T4 phage DNA. I. Complex formation of replicative DNA.

1. Properties of the nonlethal recombinational repair x and y mutants of bacteriophage T4. II. DNA synthesis.

2. das Mutation in bacteriophage T4D does not suppress an amber mutation in T4 gene 59.

3. Membrane-associated DNase activity controlled by genes 46 and 47 of bacteriophage T4D and elevated DNase activity associated with the T4 das mutation.