Literature DB >> 4583184

Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis.

S B Mills, M Bloch, F E Bruckner.   

Abstract

A double-blind cross-over study of ketoprofen (Orudis) 150 mg daily and ibuprofen (Brufen) 1,200 mg daily was carried out in 35 outpatients with rheumatoid arthritis. Results suggest that analgesic and anti-inflammatory activity of ketoprofen is superior to that of ibuprofen. Significantly greater pain relief (P < 0.05) and reduction in joint circumference (P < 0.01) was obtained with ketoprofen than with ibuprofen. Side effects of the drugs were comparable and not serious.

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Year:  1973        PMID： 4583184      PMCID： PMC1587224          DOI： 10.1136/bmj.4.5884.82

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  8 in total

1.  THE FEET OF CLAY OF THE DOUBLE-BLIND TRIAL.

Authors:  B W CROMIE
Journal:  Lancet       Date:  1963-11-09       Impact factor: 79.321

2.  DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.

Authors: 
Journal:  Ann Rheum Dis       Date:  1959-03       Impact factor: 19.103

3.  Orudis in management of rheumatoid arthritis and osteoarthrosis of the hip: comparison with indomethacin.

Authors:  A N Gyory; M Bloch; H C Burry; R Grahame
Journal:  Br Med J       Date:  1972-11-18

4.  Double-blind cross-over study of Orudis and placebo in fifty patients with rheumatoid arthritis.

Authors:  D W Zutshi; S Marr; M Bloch; R M Mason
Journal:  Rheumatol Rehabil       Date:  1973-05

5.  Ibuprofen in the management of osteoarthrosis of the hip.

Authors:  B D Owen-Smith; H C Burry
Journal:  Rheumatol Phys Med       Date:  1972-05

6.  Analgesics and non-steroid anti-inflammatory agents in rheumatic disease.

Authors:  F D Hart
Journal:  Practitioner       Date:  1972-01

7.  The long-term benefits of ibuprofen in rheumatological practice. Interim report.

Authors:  A A Goldberg; J E Hall; J W Buckler; P G Dodsworth
Journal:  Practitioner       Date:  1971-09

8.  Studies on 2-(3-benzoylphenyl) propionic acid (Orudis). A double-blind cross-over trial in patients with rheumatoid arthritis and an assessment of its influence on hepatic drug-metabolizing enzymes.

Authors:  B J Cathcart; J D Vince; A J Gordon; M A Bell; I M Chalmers
Journal:  Ann Rheum Dis       Date:  1973-01       Impact factor: 19.103
  8 in total
  5 in total

1.  A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.

Authors:  R E Pemberton; L J Strand
Journal:  Dig Dis Sci       Date:  1979-01       Impact factor: 3.199

2.  Ketoprofen: a preliminary report of its pharmacological activity and therapeutic efficacy in rheumatic disorders.

Authors:  R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1974       Impact factor: 9.546

3.  Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration.

Authors:  T Ishizaki; T Sasaki; T Suganuma; Y Horai; K Chiba; M Watanabe; W Asuke; H Hoshi
Journal:  Eur J Clin Pharmacol       Date:  1980-11       Impact factor: 2.953

Review 4.  Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole.

Authors:  Antonio Gigante; Ignacio Tagarro
Journal:  Clin Drug Investig       Date:  2012-04-01       Impact factor: 2.859

5.  Effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen.

Authors:  A Le Liboux; M Teule; A Frydman; B Oosterhuis; J H Jonkman
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953
  5 in total

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