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Literature DB >> 4577716

Diabetes in mice after Coxsackie B 4 virus infection.

Abstract

The intraperitoneal inoculation of CD(1) mice with Coxsackie virus B(4) resulted in the raising of blood sugar levels to diabetic values 12 days after the administration of the virus. Serum insulin remained inappropriately low. Light microscopy changes in the islets of Langerhans showed mononuclear cell infiltration of the islets and marked degranulation of the beta cells. The acinar tissue appeared to be little changed. It is concluded that Coxsackie B(4) virus may cause a diabetic state compatible with islet cell damage.

Entities: Chemical Disease Species

Mesh：

Substances：
Blood Glucose
Insulin

Year: 1973 PMID： 4577716 PMCID： PMC1587954 DOI： 10.1136/bmj.3.5870.25

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

5 in total

1. Immunoassay of insulin with insulin-antibody precipitate.

Authors: C N HALES; P J RANDLE
Journal: Biochem J Date: 1963-07 Impact factor: 3.857

2. Pancreatic islet cell damage in mice produced by coxsackie B 1 and encephalomyocarditis viruses.

Authors: G E Burch; C Y Tsui; J M Harb
Journal: Experientia Date: 1972-03-15

3. Seasonal incidence of diabetes mellitus.

Authors: D R Gamble; K W Taylor
Journal: Br Med J Date: 1969-09-13

4. Viral antibodies in diabetes mellitus.

Authors: D R Gamble; M L Kinsley; M G FitzGerald; R Bolton; K W Taylor
Journal: Br Med J Date: 1969-09-13

5. Diabetes mellitus: induction in mice by encephalomyocarditis virus.

Authors: J E Craighead; M F McLane
Journal: Science Date: 1968-11-22 Impact factor: 47.728

5 in total

26 in total

1. Biochemical and ultrastructural changes in A and B cells of the islets of Langerhans of mice infected with EMC virus.

Authors: F Zaheer; S L Howell; K W Taylor; T J Coleman; D R Gamble
Journal: Diabetologia Date: 1979-07 Impact factor: 10.122

2. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: viruses, autoimmunity and immunoregulation.

Authors: C M Filippi; M G von Herrath
Journal: Clin Exp Immunol Date: 2010-04 Impact factor: 4.330

9. Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.

Authors: L N Hellqvist; C J Rhodes; K W Taylor
Journal: Diabetologia Date: 1984-05 Impact factor: 10.122

10. Studies on the frequency and associations of islet-cell antibodies in juvenile diabetes mellitus.

Authors: E R Richens; J Quilley; M Hartog
Journal: Acta Diabetol Lat Date: 1978 Sep-Dec

Diabetes in mice after Coxsackie B 4 virus infection.

1. Immunoassay of insulin with insulin-antibody precipitate.

2. Pancreatic islet cell damage in mice produced by coxsackie B 1 and encephalomyocarditis viruses.

3. Seasonal incidence of diabetes mellitus.

4. Viral antibodies in diabetes mellitus.

5. Diabetes mellitus: induction in mice by encephalomyocarditis virus.

1. Biochemical and ultrastructural changes in A and B cells of the islets of Langerhans of mice infected with EMC virus.

2. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: viruses, autoimmunity and immunoregulation.

3. Viral and epidemiological studies.

4. Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.

5. Coxsackie B4 viruses with the potential to damage beta cells of the islets are present in clinical isolates.

6. The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice.

7. Coxsackie B4 viral infection, anti-islet immunity and immunogenetics in insulin-dependent diabetes mellitus.

8. Pancreatic lesions induced in rabbits and guinea-pigs with pancreatic antigens.

9. Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.

10. Studies on the frequency and associations of islet-cell antibodies in juvenile diabetes mellitus.