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Literature DB >> 45776

Proposed knobs-into-holes packing for several membrane proteins.

Abstract

We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.

Entities: Chemical

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Year: 1978 PMID： 45776 DOI： 10.3109/09687687809063855

Source DB: PubMed Journal: Membr Biochem ISSN： 0149-046X

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Cited

8 in total

1. A structural model of EmrE, a multi-drug transporter from Escherichia coli.

Authors: Kay-Eberhard Gottschalk; Misha Soskine; Shimon Schuldiner; Horst Kessler
Journal: Biophys J Date: 2004-06 Impact factor: 4.033

2. The human erythrocyte anion-transport protein. Partial amino acid sequence, conformation and a possible molecular mechanism for anion exchange.

Authors: C J Brock; M J Tanner; C Kempf
Journal: Biochem J Date: 1983-09-01 Impact factor: 3.857

Review 3. Hydrogen bonded chain mechanisms for proton conduction and proton pumping.

Authors: J F Nagle; S Tristram-Nagle
Journal: J Membr Biol Date: 1983 Impact factor: 1.843

4. Structural models of TREK channels and their gating mechanism.

Authors: Adina Milac; Andriy Anishkin; Sarosh N Fatakia; Carson C Chow; Sergei Sukharev; H Robert Guy
Journal: Channels (Austin) Date: 2011-01-01 Impact factor: 2.581

5. A small protein in model membranes: a time-resolved fluorescence and ESR study on the interaction of M13 coat protein with lipid bilayers.

Authors: J C Sanders; M F Ottaviani; A van Hoek; A J Visser; M A Hemminga
Journal: Eur Biophys J Date: 1992 Impact factor: 1.733

Proposed knobs-into-holes packing for several membrane proteins.

1. A structural model of EmrE, a multi-drug transporter from Escherichia coli.

2. The human erythrocyte anion-transport protein. Partial amino acid sequence, conformation and a possible molecular mechanism for anion exchange.

Review 3. Hydrogen bonded chain mechanisms for proton conduction and proton pumping.

4. Structural models of TREK channels and their gating mechanism.

5. A small protein in model membranes: a time-resolved fluorescence and ESR study on the interaction of M13 coat protein with lipid bilayers.

6. Analysis of structured and intrinsically disordered regions of transmembrane proteins.

7. Flexible Proteins at the Origin of Life.

Review 8. A decade and a half of protein intrinsic disorder: biology still waits for physics.