| Literature DB >> 4576518 |
H Schuster, D Beyersmann, M Mikolajczyk, M Schlicht.
Abstract
High-temperature treatment of thermosensitive dna mutants lysogenic for phage lambda leads to prophage induction and release of phage (at the permissive temperature) in elongation-defective mutants of the genotypes dnaB, dnaE, and dnaG. In initiation-defective mutants no prophage induction occurs at 42 C in mutants of the genotype dnaA, whereas with a dnaC mutant as well as with strain HfrH 252 (map position not yet known) phages are released at 42 C. DNA degradation at the replication fork at 42 C is observed in all dnaB(lambda) mutants tested, but not in mutants of the genotypes dnaE(lambda) and dnaG(lambda). Therefore, degradation of replication fork DNA is not a prerequisite for prophage induction.Entities:
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Year: 1973 PMID： 4576518 PMCID： PMC355195
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103