Literature DB >> 457255

Production of a mutagen from ponceau 3R by a human intestinal anaerobe.

C P Hartman, A W Andrews, K T Chung.   

Abstract

Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.

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Year:  1979        PMID： 457255      PMCID： PMC414220          DOI： 10.1128/iai.23.3.686-689.1979

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  6 in total

1.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  Reduction of azo dyes by intestinal anaerobes.

Authors:  K T Chung; G E Fulk; M Egan
Journal:  Appl Environ Microbiol       Date:  1978-03       Impact factor: 4.792

3.  Enzymatic reduction of tartrazine by Proteus vulgaris from rats.

Authors:  J J Roxon; A J Ryan; S E Wright
Journal:  Food Cosmet Toxicol       Date:  1967-11

4.  The toxicity and metabolism of mesidine and pseudocumidine in rats.

Authors:  H V Lindstrom; W C Bowie; W C Wallace; A A Nelson; O G Fitzhugh
Journal:  J Pharmacol Exp Ther       Date:  1969-06       Impact factor: 4.030

5.  Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer.

Authors:  K T Chung; G E Fulk; M W Slein
Journal:  J Natl Cancer Inst       Date:  1975-05       Impact factor: 13.506

6.  Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

Authors:  B N Ames; W E Durston; E Yamasaki; F D Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
  6 in total
  3 in total

1.  Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora.

Authors:  V W Mayer; C J Goin
Journal:  Appl Environ Microbiol       Date:  1983-02       Impact factor: 4.792

2.  Production of a fecal mutagen by Bacteroides spp.

Authors:  R L Van Tassel; D K MacDonald; T D Wilkins
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

3.  Mutagenicity testing of some commonly used dyes.

Authors:  K T Chung; G E Fulk; A W Andrews
Journal:  Appl Environ Microbiol       Date:  1981-10       Impact factor: 4.792
  3 in total

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