Literature DB >> 457181

Rimantadine but not amantadine protects Fischer rat embryo cells from transformation induced by 3-methylcholanthrene or benzo(a)pyrene.

P J Price, J I Mansfield, C M Hassett.   

Abstract

The antiviral drugs amantadine hydrochloride and rimantadine hydrochloride were tested as to their oncogenic potential using a serial line of Fischer rat embryo cells that previously had been shown to be an accurate indicator of chemicals known to be oncogenic in animal studies. Neither compound was found to have transforming activity. At slightly toxic levels, rimanbadine hydrochloride, but not amantadine hydrochloride, protected the same cell line from the transformation induced by the polycyclic hydrocarbons 3-methylcholanthrene and benzo(a)pyrene.

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Year:  1979        PMID： 457181     DOI： 10.1007/bf02618101

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  9 in total

1.  Alpha-methyl-1-adamantane-methylamine hydrochloride: inhibition of Rous and Esh sarcoma viruses in cell culture.

Authors:  A M Wallbank
Journal:  Proc Soc Exp Biol Med       Date:  1969-07

2.  Effect of 1-adamantanamine hydrochloride on Rous sarcoma virus in vitro and in vivo.

Authors:  N Oker-Blom; L Andersen
Journal:  Eur J Cancer       Date:  1966-02       Impact factor: 9.162

3.  Streptonigrin inhibition of 3-methylcholanthrene transformation in vitro.

Authors:  P J Price; W A Suk; G J Spahn; M A Chirigos; J A Lane; R J Huebner
Journal:  Proc Soc Exp Biol Med       Date:  1974-04

4.  Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride.

Authors:  N Kato; H J Eggers
Journal:  Virology       Date:  1969-04       Impact factor: 3.616

5.  The relative potencies of anti-influenza compounds.

Authors:  M Tisdale; D J Bauer
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

6.  Geldanamycin inhibition of 3-methylcholanthrene-induced rat embryo cell transformation.

Authors:  P J Price; W A Suk; P C Skeen; G J Spahn; M A Chirigos
Journal:  Proc Soc Exp Biol Med       Date:  1977-09

7.  Cordycepin inhibition of 3-methylcholanthrene-induced transformation in vitro.

Authors:  P J Price; W A Suk; R L Peters; C E Martin; T M Bellew; R J Huebner
Journal:  Proc Soc Exp Biol Med       Date:  1975-12

8.  Selective inhibition of RNA tumor virus replication in vitro and evaluation of candidate antiviral agents in vivo.

Authors:  W M Shannon
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

9.  I. In vitrol transformation of rat embryo cells: correlations with the known tumorigenic activities of chemicals in rodents.

Authors:  A E Freeman; H J Igel; P J Price
Journal:  In Vitro       Date:  1975 Mar-Apr
  9 in total

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