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Literature DB >> 4568728

Regulation of the expression of the N gene of bacteriophage lambda.

Abstract

A quantitative assay for the N protein of bacteriophage lambda has been used to study the in vivo regulation of N gene expression. The assay makes use of the observation that in a cell-free protein-synthesizing system from Escherichia coli programmed with lambdaN(-) DNA the lambda endolysin is made only if N protein is added to the reaction. The rate of synthesis of N protein in vivo is negatively controlled by the products of the CI and tof genes of the phage. Furthermore, N protein activity is extremely unstable in vivo. During normal cell growth at 35 degrees , the half-life of N protein is about 2 min.

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Year: 1973 PMID： 4568728 PMCID： PMC433273 DOI： 10.1073/pnas.70.2.421

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Genetic control of transcription during development of phage gamma.

Authors: A Skalka; B Butler; H Echols
Journal: Proc Natl Acad Sci U S A Date: 1967-08 Impact factor: 11.205

2. Control of development in temperate bacteriophages. II. Control of lysozyme synthesis.

Authors: C Dambly; M Couturier; R Thomas
Journal: J Mol Biol Date: 1968-02-28 Impact factor: 5.469

3. Regulation of lambda exonuclease. II. Joint regulation of exonuclease and a new lambda antigen.

Authors: C M Radding; D C Shreffler
Journal: J Mol Biol Date: 1966-07 Impact factor: 5.469

4. Transcription of complementary strands of phage lambda-DNA in vivo and in vitro.

Authors: S N Cohen; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

5. Genetics and physiology of defective lysogeny in K12 (lambda): studies of early mutants.

Authors: H A Eisen; C R Fuerst; L Siminovitch; R Thomas; L Lambert; L Pereira da Silva; F Jacob
Journal: Virology Date: 1966-10 Impact factor: 3.616

6. Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA.

Authors: K Taylor; Z Hradecna; W Szybalski
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

7. Dependence of "early" lambda bacteriophage RNA synthesis on bacteriophage-directed protein synthesis.

Authors: M W Konrad
Journal: Proc Natl Acad Sci U S A Date: 1968-01 Impact factor: 11.205

8. Function of the N cistron of bacteriophage lambda.

Authors: J J Protass; D Korn
Journal: Proc Natl Acad Sci U S A Date: 1966-05 Impact factor: 11.205

9. DNA replication and messenger RNA production after induction of wild-type lambda bacteriophage and lambda mutants.

Authors: A Joyner; L N Isaacs; H Echols; W S Sly
Journal: J Mol Biol Date: 1966-08 Impact factor: 5.469

10. Action of the lambda chromosome. I. Control of functions late in bacteriophage development.

Authors: W F Dove
Journal: J Mol Biol Date: 1966-08 Impact factor: 5.469

17 in total

Review 1. Little lambda, who made thee?

Authors: Max E Gottesman; Robert A Weisberg
Journal: Microbiol Mol Biol Rev Date: 2004-12 Impact factor: 11.056

2. An additional function for bacteriophage lambda rex: the rexB product prevents degradation of the lambda O protein.

Authors: R Schoulaker-Schwarz; L Dekel-Gorodetsky; H Engelberg-Kulka
Journal: Proc Natl Acad Sci U S A Date: 1991-06-01 Impact factor: 11.205

3. Efficient modification of E. coli RNA polymerase in vitro by the N gene transcription antitermination protein of bacteriophage lambda.

Authors: Y Goda; J Greenblatt
Journal: Nucleic Acids Res Date: 1985-04-11 Impact factor: 16.971

Regulation of the expression of the N gene of bacteriophage lambda.

1. Genetic control of transcription during development of phage gamma.

2. Control of development in temperate bacteriophages. II. Control of lysozyme synthesis.

3. Regulation of lambda exonuclease. II. Joint regulation of exonuclease and a new lambda antigen.

4. Transcription of complementary strands of phage lambda-DNA in vivo and in vitro.

5. Genetics and physiology of defective lysogeny in K12 (lambda): studies of early mutants.

6. Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA.

7. Dependence of "early" lambda bacteriophage RNA synthesis on bacteriophage-directed protein synthesis.

8. Function of the N cistron of bacteriophage lambda.

9. DNA replication and messenger RNA production after induction of wild-type lambda bacteriophage and lambda mutants.

10. Action of the lambda chromosome. I. Control of functions late in bacteriophage development.

Review 1. Little lambda, who made thee?

2. An additional function for bacteriophage lambda rex: the rexB product prevents degradation of the lambda O protein.

3. Efficient modification of E. coli RNA polymerase in vitro by the N gene transcription antitermination protein of bacteriophage lambda.

4. The kinetics of inhibition of Flac transfer by R100 in E. coli.

5. Stimulation of RNA chain initiation by the N gene protein of bacteriophage lambda.

6. RNA-directed cell-free synthesis of the galactose enzymes of Escherichia coli.

7. Altered bacteriophage lambda expression in cell division mutants capR(lon) of Escherichia coli K-12.

8. The ral gene of phage lambda. III. Interference with E. coli ATP dependent functions.

9. Stimulation in trans of synthesis of E. coli gal operon enzymes by lambdoid phages during low catabolite repression.

10. Regulation by N gene protein of phage lambda of anthranilate synthetase synthesis in vitro.