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Literature DB >> 4567329

Autonomy of mitochondria in Saccharomyces cerevisiae in their production of messenger RNA.

Abstract

In ts(-)136, a temperature-sensitive mutant of Saccharomyces cerevisiae, nuclear and mitochondrial RNA production can be inhibited selectively by exposure to 36 degrees and ethidium bromide, respectively. Using the programming of mitochondrial polysomes, as measured by their ability to form nascent polypeptide chains, as an assay for functional messenger RNA, we have determined its response to temperature shifts and ethidium bromide. Only ethidium bromide produced a measurable effect; in contrast the cell-sap system responded exclusively to temperature shifts. We conclude that transcription of mitochondrial DNA is sufficient and that import of messenger RNA transcribed from nuclear chromosomes makes no measurable contribution to intramitochondrial protein synthesis.

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Year: 1973 PMID： 4567329 PMCID： PMC433195 DOI： 10.1073/pnas.70.1.111

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Formate as a specific label for mitochondrial translational products.

Authors: H R Mahler; K Dawidowicz; F Feldman
Journal: J Biol Chem Date: 1972-11-25 Impact factor: 5.157

2. Incorporation of high molecular weight polynucleotides by isolated mitochondria.

Authors: R F Swanson
Journal: Nature Date: 1971-05-07 Impact factor: 49.962

3. Selective inhibition of the in vivo transcription of mitochondrial DNA by ethidium bromide and by acriflavin.

Authors: H Fukuhara; C Kujawa
Journal: Biochem Biophys Res Commun Date: 1970-11-25 Impact factor: 3.575

4. The effect of cycloheximide upon polyribosome stability in two yeast mutants defective respectively in the initiation of polypeptide chains and in messenger RNA synthesis.

Authors: L H Hartwell; H T Hutchison; T M Holland; C S McLaughlin
Journal: Mol Gen Genet Date: 1970

5. Electron microscopic visualization of mitochondrial RNA-DNA hybrids.

Authors: D Robberson; Y Aloni; G Attardi
Journal: J Mol Biol Date: 1971-01-28 Impact factor: 5.469

6. The genetic apparatus of mitochondria from Neurospora and yeast.

Authors: H Küntzel
Journal: Curr Top Microbiol Immunol Date: 1971 Impact factor: 4.291

7. The nature of mitochondrial RNA in oocytes of Xenopus laevis and its relation to mitochondrial DNA.

Authors: I B Dawid
Journal: Symp Soc Exp Biol Date: 1970

8. A membrane-associated RNA of cytoplasmic origin in HeLa cells.

Authors: B Attardi; G Attardi
Journal: Proc Natl Acad Sci U S A Date: 1967-09 Impact factor: 11.205

9. Temperature-sensitive yeast mutant defective in ribonucleic acid production.

Authors: H T Hutchison; L H Hartwell; C S McLaughlin
Journal: J Bacteriol Date: 1969-09 Impact factor: 3.490

10. Biogenesis of mitochondria. XI. A comparison of the effects of growth-limiting oxygen tension, intercalating agents, and antibiotics on the obligate aerobe Candida parapsilosis.

Authors: G M Kellerman; D R Biggs; A W Linnane
Journal: J Cell Biol Date: 1969-08 Impact factor: 10.539

12 in total

Autonomy of mitochondria in Saccharomyces cerevisiae in their production of messenger RNA.

1. Formate as a specific label for mitochondrial translational products.

2. Incorporation of high molecular weight polynucleotides by isolated mitochondria.

3. Selective inhibition of the in vivo transcription of mitochondrial DNA by ethidium bromide and by acriflavin.

4. The effect of cycloheximide upon polyribosome stability in two yeast mutants defective respectively in the initiation of polypeptide chains and in messenger RNA synthesis.

5. Electron microscopic visualization of mitochondrial RNA-DNA hybrids.

6. The genetic apparatus of mitochondria from Neurospora and yeast.

7. The nature of mitochondrial RNA in oocytes of Xenopus laevis and its relation to mitochondrial DNA.

8. A membrane-associated RNA of cytoplasmic origin in HeLa cells.

9. Temperature-sensitive yeast mutant defective in ribonucleic acid production.

10. Biogenesis of mitochondria. XI. A comparison of the effects of growth-limiting oxygen tension, intercalating agents, and antibiotics on the obligate aerobe Candida parapsilosis.

1. Nuclear cytochrome-deficient mutants of Neurospora crassa: isolation, characterization, and genetic mapping.

Review 2. Integration and regulation of mitochondrial assembly in yeast.

3. Molecular events during the release of delta-aminolevulinate dehydratase from catabolite repression.

4. Specific effects of nalidixic acid on mitochondrial gene expression in Saccharomyces cerevisiae.

5. Coupling between mitochondrial mutation and energy transduction.

6. Respiration of wild type and extrachromosomal mutants of Neurospora crassa.

7. Translation of RNA that contains polyadenylate from yeast mitochondria in an Escherichia coli ribosomal system.

8. The conditions required for the induction of petite yeast mutants by fluorinated pyrimidines.

9. Selection of extranuclear mutants of Neurospora crassa.

10. Time warping of evolutionary distant temporal gene expression data based on noise suppression.