Literature DB >> 4566451

Release of polypeptide chain initiation factor IF-2 during initiation complex formation.

A H Lockwood, P Sarkar, U Maitra.   

Abstract

Polypeptide chain initiation factor IF-2 binds to 30S ribosomal subunits. This binding is enhanced by IF-1 and IF-3. During GTP-dependent formation of a 70S initiation complex, IF-2 is released from the ribosome. During 70S initiation complex formation dependent on the methylene analogue of GTP, GMPPCH(2)P, IF-2 is not released, but remains bound to the 70S ribosome. This result suggests that IF-2 release requires GTP hydrolysis. In agreement with this presumed requirement, IF-2 functions catalytically with GTP, but stoichiometrically with GMPPCH(2)P, in bringing about 70S initiation complex formation.

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Year:  1972        PMID： 4566451      PMCID： PMC389830          DOI： 10.1073/pnas.69.12.3602

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Hydrolysis of guanosine 5'-triphosphate associated wh binding of aminoacyl transfer ribonucleic acid to ribosomes.

Authors:  J Gordon
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

2.  The interrelationship between guanosine triphosphatase and amino acid polymerization.

Authors:  Y Nishizuka; F Lipmann
Journal:  Arch Biochem Biophys       Date:  1966-09-26       Impact factor: 4.013

3.  The formation of a complex containing ribosomes, transfer factor G and A guanosine nucleotide.

Authors:  N Brot; C Spears; H Weissbach
Journal:  Biochem Biophys Res Commun       Date:  1969-03-31       Impact factor: 3.575

4.  Requirement of granosine 5'-triphosphate for ribosomal binding of aminoacyl-SRNA.

Authors:  J Lucas-Lenard; A L Haenni
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

5.  The composition of the active intermediate in the transfer of aminoacyl-RNA to ribosomes.

Authors:  J M Ravel; R L Shorey; W Shive
Journal:  Biochem Biophys Res Commun       Date:  1968-07-11       Impact factor: 3.575

6.  Formation and properties of the aminoacyl transfer ribonucleic acid-guanosine triphosphate-protein complex.

Authors:  R L Shorey; J M Ravel; C W Garner; W Shive
Journal:  J Biol Chem       Date:  1969-09-10       Impact factor: 5.157

7.  Purification and properties of initiation factor f2.

Authors:  D Kolakofsky; K Dewey; R E Thach
Journal:  Nature       Date:  1969-08-16       Impact factor: 49.962

8.  Junction of the 50S ribosomal subunit with the 30S initiation complex.

Authors:  D Kolakofsky; T Ohta; R E Thach
Journal:  Nature       Date:  1968-10-19       Impact factor: 49.962

9.  Purification and properties of initiation factor f-1.

Authors:  J W Hershey; K F Dewey; R E Thach
Journal:  Nature       Date:  1969-06-07       Impact factor: 49.962

10.  Guanosine 5'-triphosphatase activity of initiation factor f2.

Authors:  D Kolakofsky; K F Dewey; J W Hershey; R E Thach
Journal:  Proc Natl Acad Sci U S A       Date:  1968-11       Impact factor: 11.205
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  12 in total

Review 1.  Initiation of protein synthesis in bacteria.

Authors:  Brian Søgaard Laursen; Hans Peter Sørensen; Kim Kusk Mortensen; Hans Uffe Sperling-Petersen
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

2.  Effect of thiostrepton on recycling of Escherichia coli initiation factor 2.

Authors:  R Mazumder
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

Review 3.  The mechanism of peptide chain termination.

Authors:  W P Tate; C T Caskey
Journal:  Mol Cell Biochem       Date:  1974-12-20       Impact factor: 3.396

4.  Influence of guanine nucleotides and elongation factors on interaction of release factors with the ribosome.

Authors:  W P Tate; A L Beaudet; C T Caskey
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

Review 5.  Chemistry and biology of E. coli ribosomal protein L12.

Authors:  N Brot; H Weissbach
Journal:  Mol Cell Biochem       Date:  1981-04-13       Impact factor: 3.396

6.  Thiostrepton inhibition of initiation factor 1 activity in polypeptide chain initiation in Escherichia coli.

Authors:  P Sarkar; E A Stringer; U Maitra
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

7.  Lack of inhibition by L-1-chloro-4-phenyl-3-toluene-p-sulphonamidobutan-2-one (L-1-tosylamido-2-phenylethyl chloromethyl ketone) of the formation of bacterial polypeptide chain initiation complex.

Authors:  J Jonák; B F Clark
Journal:  Biochem J       Date:  1973-10       Impact factor: 3.857

Review 8.  Single-molecule analysis of translational dynamics.

Authors:  Alexey Petrov; Jin Chen; Seán O'Leary; Albert Tsai; Joseph D Puglisi
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-09-01       Impact factor: 10.005

9.  Translation initiation without IF2-dependent GTP hydrolysis.

Authors:  Attilio Fabbretti; Letizia Brandi; Pohl Milón; Roberto Spurio; Cynthia L Pon; Claudio O Gualerzi
Journal:  Nucleic Acids Res       Date:  2012-06-20       Impact factor: 16.971

10.  Heterogeneous pathways and timing of factor departure during translation initiation.

Authors:  Albert Tsai; Alexey Petrov; R Andrew Marshall; Jonas Korlach; Sotaro Uemura; Joseph D Puglisi
Journal:  Nature       Date:  2012-07-19       Impact factor: 49.962
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