Literature DB >> 456429

Brain distribution of propranolol in the rat.

J L Elghozi, G Bianchetti, P L Morselli, P Meyer.   

Abstract

The distribution and kinetics of D,L-propranolol in rat brain were examined after an intravenous injection of the drug. Measurements in brain areas and blood were performed by means of a sensitive and specific gas liquid chromatographic method. The disappearance rate in cortical areas paralleled that in blood. However D,L-propranolol decreased at a slower rate in hypothalamic and medullary nuclei. Since propranolol is believed to have central hypotensive effects, its retention by certain central nuclei involved in blood pressure regulation is of interest.

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Year:  1979        PMID： 456429     DOI： 10.1016/0014-2999(79)90201-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference.

Authors:  Laura Font; Christopher L Cunningham
Journal:  Pharmacol Biochem Behav       Date:  2012-01-21       Impact factor: 3.533

2.  Noradrenergic receptor modulation influences the acoustic parameters of pro-social rat ultrasonic vocalizations.

Authors:  Laura M Grant; Kelsey J Barth; Cagla Muslu; Cynthia A Kelm-Nelson; Vaishali P Bakshi; Michelle R Ciucci
Journal:  Behav Neurosci       Date:  2018-07-09       Impact factor: 1.912

3.  Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats.

Authors:  Hidetaka Yamada; Adrie W Bruijnzeel
Journal:  Neuropharmacology       Date:  2010-09-18       Impact factor: 5.250

4.  The short-term effects of dl-propranolol on the wake-sleep cycle of the rat are related to selective changes in preoptic cyclic AMP concentration.

Authors:  G Zamboni; E Perez; R Amici; P L Parmeggiani
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

5.  Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats.

Authors:  W J Louis; J Papanicolaou; R J Summers; F J Vajda
Journal:  Br J Pharmacol       Date:  1982-03       Impact factor: 8.739

6.  Neurocardiology shows that the central, not peripheral, action of propranolol reduces mortality following acute coronary artery occlusion in the conscious pig.

Authors:  J E Skinner
Journal:  Integr Physiol Behav Sci       Date:  1991 Apr-Jun
  6 in total

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