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Literature DB >> 4562751

Recognition of nonsense codons in mammalian cells.

Abstract

The tritiated trinucleotide UGA was used in a binding assay to detect transfer RNAs that recognize this nonsense codon from calf-liver cells. Acylation of transfer RNA with labeled amino acids and determination of codon responses of aminoacyl-tRNAs demonstrate that a species of seryl-tRNA and a species of arginyl-tRNA recognize the codon UGA. Slight responses of cysteinyl-tRNA and of trytophanyl-tRNA to the codon UGA were also observed.

Entities: Chemical Species

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Year: 1972 PMID： 4562751 PMCID： PMC389697 DOI： 10.1073/pnas.69.10.3014

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Studies on the formation of transfer ribonucleic acid-ribosome complexes. 3. The formation of peptide bonds by ribosomes in the absence of supernatant enzymes.

Authors: S Pestka
Journal: J Biol Chem Date: 1968-05-25 Impact factor: 5.157

2. Sense and nonsense in the genetic code. Three exceptional triplets can serve as both chain-terminating signals and amino acid codons.

Authors: A Garen
Journal: Science Date: 1968-04-12 Impact factor: 47.728

Review 3. Suppression.

Authors: L Gorini; J R Beckwith
Journal: Annu Rev Microbiol Date: 1966 Impact factor: 15.500

4. Separation of transfer ribonucleic acids by reverse phase chromatography.

Authors: A D Kelmers; G D Novelli; M P Stulberg
Journal: J Biol Chem Date: 1965-10 Impact factor: 5.157

5. Fractionation of rat liver transfer ribonucleic acid. Isolation of tyrosine, valine, serine, and phenylalanine transfer ribonucleic acids and their coding properties.

Authors: S Nishimura; I B Weinstein
Journal: Biochemistry Date: 1969-03 Impact factor: 3.162

6. Identification of nonsense codons in yeast.

Authors: D C Hawthorne
Journal: J Mol Biol Date: 1969-07-14 Impact factor: 5.469

7. The RNA code and protein synthesis.

Authors: M Nirenberg; T Caskey; R Marshall; R Brimacombe; D Kellogg; B Doctor; D Hatfield; J Levin; F Rottman; S Pestka; M Wilcox; F Anderson
Journal: Cold Spring Harb Symp Quant Biol Date: 1966

8. Multiple isoaccepting transfer RNA's in a muouse plasma cell tumor.

Authors: W K Yang; G D Novelli
Journal: Proc Natl Acad Sci U S A Date: 1968-01 Impact factor: 11.205

9. Studies on codons for tyrosyl transfer ribonucleic acid and lysyl transfer ribonucleic acid of yeast.

Authors: D M Brown; B F Clark; M J Tanner
Journal: Eur J Biochem Date: 1968-09-24

10. Fine structure of RNA codewords recognized by bacterial, amphibian, and mammalian transfer RNA.

Authors: R E Marshall; C T Caskey; M Nirenberg
Journal: Science Date: 1967-02-17 Impact factor: 47.728

8 in total

1. Patterns of codon recognition by isoacceptor aminoacyl-tRNAs from wheat germ.

Authors: D Hatfield; M Rice
Journal: Nucleic Acids Res Date: 1978-10 Impact factor: 16.971

2. Changes in the serine-specific transfer ribonucleic acid pattern of guinea pig epidermis after corticosteroid treatment.

Authors: E Schwarz; H Gottschling
Journal: Arch Dermatol Res Date: 1980 Impact factor: 3.017

3. Opal suppressor serine tRNAs from bovine liver form phosphoseryl-tRNA.

Authors: D Hatfield; A Diamond; B Dudock
Journal: Proc Natl Acad Sci U S A Date: 1982-10 Impact factor: 11.205

4. Identification of amino acids inserted during suppression of UAA and UGA termination codons at the gag-pol junction of Moloney murine leukemia virus.

Authors: Y X Feng; T D Copeland; S Oroszlan; A Rein; J G Levin
Journal: Proc Natl Acad Sci U S A Date: 1990-11 Impact factor: 11.205