Literature DB >> 4562254

Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes.

M Mangkornkanok, A S Markowitz, H A Battifora.   

Abstract

Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.

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Year:  1972        PMID: 4562254     DOI: 10.1126/science.178.4058.316

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  2 in total

Review 1.  Thyroid peroxidase as an antigen in autoimmune thyroiditis.

Authors:  A P Weetman
Journal:  Clin Exp Immunol       Date:  1990-04       Impact factor: 4.330

2.  Anti-thyroglobulin autoantibodies in sera from patients with chronic thyroiditis and from healthy subjects: differences in cross-reactivity with thyroid peroxidase.

Authors:  N Naito; K Saito; T Hosoya; O Tarutani; S Sakata; T Nishikawa; H Niimi; H Nakajima; Y Kohno
Journal:  Clin Exp Immunol       Date:  1990-04       Impact factor: 4.330

  2 in total

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