Literature DB >> 455916

An unusual case of carbamazepine poisoning with a near-fatal relapse after two days.

R A de Zeeuw, H G Westenberg, E van der Kleijn, J S Gimbrère.   

Abstract

A severe case of carbamazepine is described in which the drug and its major metabolite were monitored by means of HPLC. After 2 days of treatment a dramatic rise in plasma concentration of carbamazepine and its metabolite was observed, accompanied by a relapse into deep coma, then followed by a rapid elimination of the drugs and complete recovery within 4 days. The possible mechanisms underlying these phenomena and potential therapeutic measures are discussed.

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Year:  1979        PMID： 455916     DOI： 10.3109/15563657908992443

Source DB:  PubMed          Journal:  Clin Toxicol        ISSN： 0009-9309            Impact factor:   4.467


  7 in total

Review 1.  Pharmacokinetics of drugs in overdose.

Authors:  Y J Sue; M Shannon
Journal:  Clin Pharmacokinet       Date:  1992-08       Impact factor: 6.447

2.  Successful treatment of a case with concurrent ingestion of carbamazepine overdose and grapefruit juice.

Authors:  Katsunori Mochizuki; Yujiro Hamano; Hiroshi Miyama; Kazuki Arakawa; Takashi Kobayashi; Hiroshi Imamura
Journal:  Acute Med Surg       Date:  2015-04-28

3.  Signs and symptoms of carbamazepine overdose.

Authors:  S Schmidt; M Schmitz-Buhl
Journal:  J Neurol       Date:  1995-02       Impact factor: 4.849

Review 4.  Carbamazepine overdose. Features of 33 cases.

Authors:  J F Seymour
Journal:  Drug Saf       Date:  1993-01       Impact factor: 5.606

5.  Carbamazepine poisoning: a case report.

Authors:  A Tartara; R Manni; M Maurelli; G Sandrini; F Savoldi
Journal:  Ital J Neurol Sci       Date:  1986-02

Review 6.  Carbamazepine toxicity and poisoning. Incidence, clinical features and management.

Authors:  L Durelli; U Massazza; R Cavallo
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Mar-Apr

Review 7.  Extracorporeal treatment for carbamazepine poisoning: systematic review and recommendations from the EXTRIP workgroup.

Authors:  Marc Ghannoum; Christopher Yates; Tais F Galvao; Kevin M Sowinski; Thi Hai Vân Vo; Andrew Coogan; Sophie Gosselin; Valery Lavergne; Thomas D Nolin; Robert S Hoffman
Journal:  Clin Toxicol (Phila)       Date:  2014-10-30       Impact factor: 4.467
  7 in total

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