Effect of synthetic luteinizing hormone releasing hormone (LH/FSH-RH) in women with menstrual disorders.

Synthetic luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) (50 mug) was given intravenously to six women with oligomenorrhoea and to four women with secondary amenorrhoea. Peripheral venous blood was withdrawn at regular intervals over a 24-hour period. The concentrations of LH, FSH, and oestradiol-17beta were determined by radioimmunoassay. In all subjects there was a variable rise in LH (3-16 times the mean basal level): in six a small rise in FSH (two to three times the mean basal level) and in seven a twofold to threefold rise in oestradiol three to eight hours after the rise in gonadotrophins.