Literature DB >> 4557029

In-vivo cytogenetic effects of perphenazine and chlorpromazine: a negative study.

M M Cohen, E Lieber, H N Schwartz.   

Abstract

No evidence was found that either perphenazine or chlorpromazine induced chromosomal damage in patients given the drugs. These results were reached independently at two separate laboratories; earlier reports of possible adverse cytogenetic effects of these drugs can probably be discounted.

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Year:  1972        PMID： 4557029      PMCID： PMC1788505          DOI： 10.1136/bmj.3.5817.21

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  7 in total

1.  Chromosome preparations of leukocytes cultured from human peripheral blood.

Authors:  P S MOORHEAD; P C NOWELL; W J MELLMAN; D M BATTIPS; D A HUNGERFORD
Journal:  Exp Cell Res       Date:  1960-09       Impact factor: 3.905

2.  In vivo and in vitro chromosomal damage induced by LSD-25.

Authors:  M M Cohen; K Hirschhorn; W A Frosch
Journal:  N Engl J Med       Date:  1967-11-16       Impact factor: 91.245

3.  Some effects of diazepam in human cells in vitro.

Authors:  M A Stenchever; R B Frankel
Journal:  Am J Obstet Gynecol       Date:  1969-03-15       Impact factor: 8.661

4.  Cytogenetic effects of tranquilizing drugs in vivo and in vitro.

Authors:  M M Cohen; K Hirschhorn; W A Frosch
Journal:  JAMA       Date:  1969-03-31       Impact factor: 56.272

5.  Chlordiazepoxide and diazepam: absence of effects on the chromosomes of diploid human fibroblast cells.

Authors:  G R Staiger
Journal:  Mutat Res       Date:  1969 Jan-Feb       Impact factor: 2.433

6.  Chromosome studies on bone marrow from Chinese hamsters treated with benzodiazepine tranquillizers and cyclophosphamide.

Authors:  W Schmid; G R Staiger
Journal:  Mutat Res       Date:  1969 Jan-Feb       Impact factor: 2.433

7.  Chromosome abnormalities in patients treated with chlorpromazine, perphenazine, and lysergide.

Authors:  J Nielsen; U Friedrich; T Tsuboi
Journal:  Br Med J       Date:  1969-09-13
  7 in total
  1 in total

1.  Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro.

Authors:  S Madle; G Obe; H Schroeter; J Herha; A Pietzcker
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132
  1 in total

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