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Literature DB >> 4554459

8(9),22 -Ergostadiene-3 -ol, an ergosterol precursor accumulated in wild-type and mutants of yeast.

L W Parks, F T Bond, E D Thompson, P R Starr.

Abstract

Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Delta(8(9),22)-ergostadiene-3beta-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis.

Entities: Chemical Species

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Year: 1972 PMID： 4554459

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

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Cited

12 in total

Review 1. Lipids of yeasts.

Authors: J B Rattray; A Schibeci; D K Kidby
Journal: Bacteriol Rev Date: 1975-09

2. Relationship between polyene resistance and sterol compositions in Cryptococcus neoformans.

Authors: S J Kim; J Kwon-Chung; G W Milne; W B Hill; G Patterson
Journal: Antimicrob Agents Chemother Date: 1975-01 Impact factor: 5.191

3. Yeast sterol esters and their relationship to the growth of yeast.

Authors: R B Bailey; L W Parks
Journal: J Bacteriol Date: 1975-11 Impact factor: 3.490

4. Corresponding changes in kynurenine hydroxylase activity, membrane fluidity, and sterol composition in Saccharomyces cerevisiae mitochondria.

Authors: C A McLean-Bowen; L W Parks
Journal: J Bacteriol Date: 1981-03 Impact factor: 3.490

5. Intracytoplasmic membrane, phospholipid, and sterol content of Methylobacterium organophilum cells grown under different conditions.

Authors: T E Patt; R S Hanson
Journal: J Bacteriol Date: 1978-05 Impact factor: 3.490

8(9),22 -Ergostadiene-3 -ol, an ergosterol precursor accumulated in wild-type and mutants of yeast.

Review 1. Lipids of yeasts.

2. Relationship between polyene resistance and sterol compositions in Cryptococcus neoformans.

3. Yeast sterol esters and their relationship to the growth of yeast.

4. Corresponding changes in kynurenine hydroxylase activity, membrane fluidity, and sterol composition in Saccharomyces cerevisiae mitochondria.

5. Intracytoplasmic membrane, phospholipid, and sterol content of Methylobacterium organophilum cells grown under different conditions.

6. Polyene-resistant mutants of Aspergillus fennelliae: sterol content and genetics.

7. Aspects of sterol metabolism in the yeast Saccharomyces cerevisiae and in Phytophthora.

8. Inhibition of Sterol Biosynthesis in Chlorella sorokiniana by Triparanol.

9. Polyene-resistant mutants of Aspergillus fennelliae: identification of sterols.

10. Sterol methylation in Saccharomyces cerevisiae.