Literature DB >> 455270

Photodynamic inactivation of cancer cells in vitro. Effect of irradiation temperature and dose fractionation.

J Moan, T Christensen.   

Abstract

Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient when it is fractionated than when it is given in a single exposire. These findings may be taken advantage of in future photochemotherapy of cancer.

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Year:  1979        PMID: 455270     DOI: 10.1016/s0304-3835(79)80090-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  3 in total

1.  Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.

Authors:  T Christensen
Journal:  Br J Cancer       Date:  1981-09       Impact factor: 7.640

2.  Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.

Authors:  T Christensen; A Wahl; L Smedshammer
Journal:  Br J Cancer       Date:  1984-07       Impact factor: 7.640

3.  The effect of fractionation of light treatment on necrosis and vascular function of normal skin following photodynamic therapy.

Authors:  K Benstead; J V Moore
Journal:  Br J Cancer       Date:  1988-09       Impact factor: 7.640

  3 in total

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