Literature DB >> 455145

Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol.

S W Tang, D M Helmeste, H C Stancer.   

Abstract

The effects of some antidepressants on brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) were studied in the rat. Desipramine decreased and mianserine increased the brain total MHPG concentration while the other antidepressants had no effect. They were also the only antidepressants that attenuated the lowering action of clonidine on brain total MHPG, but possibly through different mechanisms. Two tertiary amine tricyclic antidepressants, amitriptyline and imipramine, appeared to enhance the lowering action of clonidine on brain total MHPG. The results suggest that antidepressants are heterogeneous in their action on brain noradrenergic mechanisms in the rat.

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Year:  1979        PMID： 455145     DOI： 10.1139/y79-067

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN： 0008-4212            Impact factor:   2.273


  8 in total

1.  Effect of antidepressant drugs on serotonergic and adrenergic receptors.

Authors:  S W Tang; P Seeman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-04       Impact factor: 3.000

2.  An investigation of the role of 5-hydroxytryptamine in the attenuation of presynaptic alpha 2-adrenoceptor-mediated responses by antidepressant treatments.

Authors:  D J Heal; E M Hurst; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Sex-related differences in central adrenergic function and responsiveness to repeated administration of desipramine or electroconvulsive shock.

Authors:  D J Heal; L M Bristow; E M Hurst; J M Elliott; W R Buckett
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

4.  Tricyclic antidepressants vary in decreasing alpha 2-adrenoceptor sensitivity with chronic treatment: assessment with clonidine inhibition of acoustic startle.

Authors:  M Davis; D B Menkes
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

5.  Chronic treatment with some atypical antidepressants increases the brain level of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rats.

Authors:  E Przegaliński; A Kordecka-Magiera; E Mogilnicka; J Maj
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

6.  Some effects of chronic antidepressant treatments on rat brain monoaminergic systems.

Authors:  M F Sugrue
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

7.  Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic alpha 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride.

Authors:  D J Heal; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

8.  Presynaptic alpha-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats.

Authors:  I Zebrowska-Lupina
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
  8 in total

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