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Literature DB >> 4550660

Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae.

Abstract

Yeast mutants deficient in orotidine-5'-phosphate (OMP) pyrophosphorylase activity have been obtained. The gene encoding this enzyme is unlinked to the four pyrimidine genes previously described. The specific activity of OMP pyrophosphorylase remains constant under all of the physiological conditions used to repress, to derepress, or to induce pyrimidine biosynthesis. This enzyme appears, therefore, to escape the scheme of regulation by mixed repression and induction controlling the other enzymes of the pyrimidine pathway.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1972 PMID： 4550660 PMCID： PMC247267 DOI： 10.1128/jb.109.1.196-202.1972

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

12 in total

1. Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate.

Authors: I LIEBERMAN; A KORNBERG; E S SIMMS
Journal: J Biol Chem Date: 1955-07 Impact factor: 5.157

2. Purification of yeast inorganic pyrophosphatase.

Authors: L A HEPPEL; R J HILMOE
Journal: J Biol Chem Date: 1951-09 Impact factor: 5.157

3. The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.

Authors: P Reyes
Journal: Biochemistry Date: 1969-05 Impact factor: 3.162

Review 4. Pyrimidine metabolism in microorganisms.

Authors: G A O'Donovan; J Neuhard
Journal: Bacteriol Rev Date: 1970-09

5. Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype.

Authors: L Pinsky; R S Krooth
Journal: Proc Natl Acad Sci U S A Date: 1967-04 Impact factor: 11.205

6. Studies on the control of pyrimidine biosynthesis in human diploid cell strains. II. Effects of 5-azaorotic acid, barbituric acid, and pyrimidine precursors on cellular phenotype.

Authors: L Pinsky; R S Krooth
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

7. Genetic mapping in Saccharomyces.

Authors: R K Mortimer; D C Hawthorne
Journal: Genetics Date: 1966-01 Impact factor: 4.562

8. Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae.

Authors: R Jund; F Lacroute
Journal: J Bacteriol Date: 1970-06 Impact factor: 3.490

9. Pyrimidine synthesis in Neurospora crassa: gene-enzyme relationships.

Authors: D F Caroline
Journal: J Bacteriol Date: 1969-12 Impact factor: 3.490

10. Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae.

Authors: F Lacroute
Journal: J Bacteriol Date: 1968-03 Impact factor: 3.490

16 in total

1. Extrachromosomal inheritance in Schizosaccharomyces pombe. I. Evidence for an extrakaryotically inherited mutation conferring resistance to antimycin.

Authors: K Wolf; G Burger; B Lang; F Kaudewitz
Journal: Mol Gen Genet Date: 1976-02-27

2. Correlation between restriction map, genetic map and catalytic functions in the gene complex URA2.

Authors: S Potier; J L Souciet; F Lacroute
Journal: Mol Gen Genet Date: 1987-09

3. Selection and characterization of ura5 mutants of Histoplasma capsulatum.

Authors: P L Worsham; W E Goldman
Journal: Mol Gen Genet Date: 1988-10

4. Direct selective techniques for the isolation of pyrimidine auxotrophs in yeast.

Authors: M L Bach; F Lacroute
Journal: Mol Gen Genet Date: 1972

5. A regulatory interaction between pyrimidine and purine biosyntheses via ureidosuccinic acid.

Authors: C T Korch; F Lacroute; F Exinger
Journal: Mol Gen Genet Date: 1974

6. Genes coding for the structure of the acid phosphatases in Saccharomyces cerevisiae.

Authors: A Toh-e; S Kakimoto
Journal: Mol Gen Genet Date: 1975-12-30

7. Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.

Authors: Toshiro Sakaguchi; Kensuke Nakajima; Yusuke Matsuda
Journal: Plant Physiol Date: 2011-03-02 Impact factor: 8.340

8. Ultracytochemical localization of the vacuolar marker enzymes alkaline phosphatase, adenosine triphosphatase, carboxypeptidase Y and aminopeptidase reveal new concept of vacuole biogenesis in Saccharomyces cerevisiae.

Authors: J Vorísek
Journal: Histochemistry Date: 1989

9. Heterospecific cloning of Arabidopsis thaliana cDNAs by direct complementation of pyrimidine auxotrophic mutants of Saccharomyces cerevisiae. I. Cloning and sequence analysis of two cDNAs catalysing the second, fifth and sixth steps of the de novo pyrimidine biosynthesis pathway.

Authors: F Nasr; N Bertauche; M E Dufour; M Minet; F Lacroute
Journal: Mol Gen Genet Date: 1994-07-08

10. The PYR1 gene of the plant pathogenic fungus Colletotrichum graminicola: selection by intraspecific complementation and sequence analysis.

Authors: J B Rasmussen; D G Panaccione; G C Fang; R M Hanau
Journal: Mol Gen Genet Date: 1992-10