Literature DB >> 4542734

Antibodies to a specific surface antigen of T cells in human sera inhibiting mixed leukocyte culture reactions.

P Wernet, H G Kunkel.   

Abstract

Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated with inhibition of the responder cells in the mixed leukocyte culture reactions. This reacted with an antigen on T cells and thymocytes which on sodium dodecyl sulfate acrylamide gel electrophoresis showed a molecular weight of approximately 15,000 daltons. The possible relation of this antigen to T cell receptors and products of immune response genes is discussed.

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Year:  1973        PMID： 4542734      PMCID： PMC2180576          DOI： 10.1084/jem.138.4.1021

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus.

Authors:  R B Lies; R P Messner; R C Williams
Journal:  Arthritis Rheum       Date:  1973 May-Jun

2.  Inhibition of the mixed lymphocyte reaction by antibodies.

Authors:  J P Revillard; M Robert; H Betuel; M Latour; M Bonneau; J Brochier; J Traeger
Journal:  Transplant Proc       Date:  1972-06       Impact factor: 1.066

3.  Three closely linked genetic systems relevant to transplantation.

Authors:  E J Yunis; D B Amos
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

Review 4.  Histocompatibility-linked immune response genes.

Authors:  B Benacerraf; H O McDevitt
Journal:  Science       Date:  1972-01-21       Impact factor: 47.728

5.  Transplantation antigens: introductory symposium. Mixed leukocyte cultures and HL-A antigens. I. Reactivity of young fetuses, newborns and mothers at delivery.

Authors:  R Ceppellini; G D Bonnard; F Coppo; V C Miggiano; M Pospisil; E S Curtoni; M Pellegrino
Journal:  Transplant Proc       Date:  1971-03       Impact factor: 1.066

6.  Graft survival in unrelated donor--recipient pairs matched for MLC and HL-A.

Authors:  J J van Rood; C T Koch; J P van Hooff; A van Leeuwen; J G van den Tweel; E Frederiks; H M Schippers; G Hendriks; G J van der Steen
Journal:  Transplant Proc       Date:  1973-03       Impact factor: 1.066

7.  Isolation of heavy and light chains of immunoglobulin from the surfaces of lymphoid cells.

Authors:  S Baur; E S Vitetta; C J Sherr; I Schenkein; J W Uhr
Journal:  J Immunol       Date:  1971-04       Impact factor: 5.422

8.  Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.

Authors:  R J Hartzman; M Segall; M L Bach; F H Bach
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

9.  Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.

Authors:  F H Bach; M B Widmer; M L Bach; J Klein
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307

10.  Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor.

Authors:  W H Brooks; M G Netsky; D E Normansell; D A Horwitz
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307
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  45 in total

1.  An IgG thymolytic autoantibody in rats which has specificity for a subpopulation of T cells.

Authors:  R J Perper; A L Oronsky; M Sanda
Journal:  Immunology       Date:  1976-12       Impact factor: 7.397

Review 2.  Immunopathogenesis of the neuropsychiatric manifestations of systemic lupus erythematosus.

Authors:  H G Bluestein; K D Pischel; V L Woods
Journal:  Springer Semin Immunopathol       Date:  1986

3.  Cloning of T-lymphocytes in systemic lupus erythematosus.

Authors:  S Whittingham; B Rodger; J V Matthews; I R Mackay
Journal:  Clin Exp Immunol       Date:  1978-10       Impact factor: 4.330

4.  Studies of immune functions of patients with systemic lupus erythematosus. Complement-dependent immunoglobulin M anti-thymus-derived cell antibodies preferentially inactivate suppressor cells.

Authors:  T Sakane; A D Steinberg; J P Reeves; I Green
Journal:  J Clin Invest       Date:  1979-05       Impact factor: 14.808

5.  Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen.

Authors:  A B Gottlieb; R G Lahita; N Chiorazzi; H G Kunkel
Journal:  J Clin Invest       Date:  1979-05       Impact factor: 14.808

Review 6.  Lymphocytotoxic antibodies in SLE: a review of the literature.

Authors:  C Osman; A J Swaak
Journal:  Clin Rheumatol       Date:  1994-03       Impact factor: 2.980

7.  Fractionation of cells on a discontinuous Ficoll gradient. Study of subpopulations of human T cells using anti-T-cell antibodies from patients with systemic lupus erythematosus.

Authors:  W Glinski; M E Gershwin; A D Steinberg
Journal:  J Clin Invest       Date:  1976-03       Impact factor: 14.808

8.  Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.

Authors:  H G Bluestein; N J Zvaifler
Journal:  J Clin Invest       Date:  1976-02       Impact factor: 14.808

9.  Antibodies to T cells in patients with systemic lupus erythematosus can induce antibody-dependent cell-mediated cytotoxicity against human T cells.

Authors:  S Kumagai; A D Steinberg; I Green
Journal:  J Clin Invest       Date:  1981-03       Impact factor: 14.808

10.  The pathogenesis of neuropsychiatric lupus.

Authors:  J A Denburg; P Temesvari
Journal:  Can Med Assoc J       Date:  1983-02-01       Impact factor: 8.262
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