Literature DB >> 4538908

A gas chromatographic method of measuring residual water in freeze-dried smallpox vaccine.

L C Robinson.   

Abstract

A new method for the accurate determination of residual water in freeze-dried vaccines is described. Tests may be carried out on very small samples in sealed ampoules. The method is based on the adsorption of water from the vaccine with benzene and its estimation by gas chromatography. It appears that the residual water and total nitrogen content are important factors in the stability of the vaccine.

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Year:  1972        PMID： 4538908      PMCID： PMC2480811     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  9 in total

1.  The titration of vaccinia virus on the chorioallantoic membrane of the developing chick embryo.

Authors:  J C WESTWOOD; P H PHIPPS; E A BOULTER
Journal:  J Hyg (Lond)       Date:  1957-03

2.  Preparation of dried antigen and antiserum for the agglutination-inhibition test for virus influenza.

Authors:  M R HILLEMAN; E L BUESCHER; J E SMADEL
Journal:  Public Health Rep       Date:  1951-09-21       Impact factor: 2.792

3.  Factors Affecting the Viability of Serratia marcescens During Dehydration and Storage.

Authors:  H B Naylor; P A Smith
Journal:  J Bacteriol       Date:  1946-11       Impact factor: 3.490

4.  The survival of bacteria during and after drying.

Authors:  R M FRY; R I N GREAVES
Journal:  J Hyg (Lond)       Date:  1951 Jun-Sep

5.  Some physical factors that influence the survival of Brucella abortus during freeze-drying.

Authors:  R S HUTTON; R J HILMOE; J L ROBERTS
Journal:  J Bacteriol       Date:  1951-03       Impact factor: 3.490

6.  A simple and sensitive procedure for the microdtermination of nitrogen in biological materials.

Authors:  G R Jones
Journal:  Lab Pract       Date:  1967-12

7.  [Stability and preservability of freeze-dried small-pox vaccine with different moisture contents].

Authors:  M Nomura; C Nishimura; M Kitaoka
Journal:  Jpn J Med Sci Biol       Date:  1965-10

8.  Stability of suspensions of influenza virus dried to different contents of residual moisture by sublimation in vacuo.

Authors:  D Greiff; W A Rightsel
Journal:  Appl Microbiol       Date:  1968-06

9.  Stabilities of dried suspensions of influenza virus sealed in a vacuum or under different gases.

Authors:  D Greiff; W A Rightsel
Journal:  Appl Microbiol       Date:  1969-06
  9 in total

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