Literature DB >> 4531039

A new antitumoral agent: 9-hydroxyellipticine. Possibility of a rational design of anticancerous drugs in the series of DNA intercalating drugs.

J B Le Pecq, C Gosse, C Paoletti.   

Abstract

The designing of DNA intercalating drugs with high DNA affinity in the series of ellipticine has led to a new antitumoral agent, 9-hydroxyellipticine, which has a high DNA affinity, a high activity on L 1210 mice leukemia, and a lack of toxicity at therapeutic dose. The possible correlations among chemical structure, DNA reactivity, and pharmacological activity of DNA intercalating drugs are discussed.

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Year:  1974        PMID： 4531039      PMCID： PMC434043          DOI： 10.1073/pnas.71.12.5078

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  A new DNA intercalating drug: Methoxy-9-ellipticine.

Authors:  B Festy; J Poisson; C Paoletti
Journal:  FEBS Lett       Date:  1971-10-01       Impact factor: 4.124

2.  ACTINOMYCIN BINDING TO DNA: MECHANISM AND SPECIFICITY.

Authors:  M GELLERT; C E SMITH; D NEVILLE; G FELSENFELD
Journal:  J Mol Biol       Date:  1965-03       Impact factor: 5.469

3.  EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIV. FURTHER STUDY OF CERTAIN BASIC CONCEPTS UNDERLYING CHEMOTHERAPY OF LEUKEMIA.

Authors:  H E SKIPPER; F M SCHABEL; W S WILCOX
Journal:  Cancer Chemother Rep       Date:  1965-04

4.  [Extraction of desoxyribonucleic acid from different tissues using papain].

Authors:  G AUBIN; P CHENAILLE; N LAMONTHEZIE; C PAOLETTI
Journal:  Biochim Biophys Acta       Date:  1963-07-30

5.  Methoxy-9-ellipticine lactate. 3. Clinical screening: its action in acute myeloblastic leukaemia.

Authors:  G Mathé; M Hayat; F De Vassal; L Schwarzenberg; M Schneider; J R Schlumberger; C Jasmin; C Rosenfeld
Journal:  Rev Eur Etud Clin Biol       Date:  1970-05

6.  Decay of fluorescence emission anisotropy of the ethidium bromide-DNA complex. Evidence for an internal motion in DNA.

Authors:  P Wahl; J Paoletti; J B Le Pecq
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205

7.  DNA of bacteriophage PM2: a closed circular double-stranded molecule.

Authors:  R T Espejo; E S Canelo; R L Sinsheimer
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205

8.  The change of the torsion of the DNA helix caused by intercalation. II. Measurement of the relative change of torsion induced by various intercalating drugs.

Authors:  J M Saucier; B Festy; J B Le Pecq
Journal:  Biochimie       Date:  1971       Impact factor: 4.079

9.  [Studies on the toxicity of 9-hydroxyellipticine].

Authors:  C Paoletti; S Cros; R Sorbara; C Gosse; Y Tollon; C Moisand
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1974-03-04

10.  Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). Isolation of the alkaloids and study of the antitumor properties of 9-methoxyellipticine.

Authors:  G H Svoboda; G A Poore; M L Montfort
Journal:  J Pharm Sci       Date:  1968-10       Impact factor: 3.534
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  18 in total

1.  DNA polyintercalating drugs: DNA binding of diacridine derivatives.

Authors:  J B Le Pecq; M Le Bret; J Barbet; B Roques
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

2.  Mechanism-based common reactivity pattern (COREPA) modelling of aryl hydrocarbon receptor binding affinity.

Authors:  P I Petkov; J C Rowlands; R Budinsky; B Zhao; M S Denison; O Mekenyan
Journal:  SAR QSAR Environ Res       Date:  2010-01-01       Impact factor: 3.000

3.  9-[(10-(aden-9-yl)-4,8-diazadecyl)amino]-6-chloro-2-methoxy-acridine incises DNA at apurinic sites.

Authors:  J F Constant; T R O'Connor; J Lhomme; J Laval
Journal:  Nucleic Acids Res       Date:  1988-03-25       Impact factor: 16.971

4.  Sequence-selective binding of an ellipticine derivative to DNA.

Authors:  C Bailly; C OhUigin; C Rivalle; E Bisagni; J P Hénichart; M J Waring
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

5.  A reexamination of the problem of resonance energy transfer between DNA intercalated chromophores using bisintercalating compounds.

Authors:  M Le Bret; J B Le Pecq; J Barbet; B P Roques
Journal:  Nucleic Acids Res       Date:  1977       Impact factor: 16.971

Review 6.  New cancer chemotherapy drugs in Europe.

Authors:  G Mathé; L M van Putten
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

7.  The multiplication of analogs, the best strategy for rapid extension of the oncostatic arsenal. How can they be compared experimentally?

Authors:  G Mathé; C Jasmin
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

8.  Microspectrofluorometry of the protonation state of ellipticine, an antitumor alkaloid, in single cells.

Authors:  F Sureau; F Moreau; J M Millot; M Manfait; B Allard; J Aubard; M A Schwaller
Journal:  Biophys J       Date:  1993-11       Impact factor: 4.033

9.  DNA-binding characterization of a novel anti-tumour benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies.

Authors:  M Tarui; M Doi; T Ishida; M Inoue; S Nakaike; K Kitamura
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

10.  Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

Authors:  J Bernadou; B Meunier; G Meunier; C Auclair; C Paoletti
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
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