Literature DB >> 4530304

Reversible "transformation" of bromodeoxyuridine-dependent cells by bromodeoxyuridine.

R L Davidson, D Horn.   

Abstract

The growth characteristics of a bromodeoxyuridine-dependent cell line that was derived from a non-contact-inhibited Syrian hamster melanoma line were studied. The dependent cells require high concentrations of bromodeoxyuridine not only for optimal growth but also for the maintenance of the non-contact-inhibited state. When grown in the absence of bromodeoxyuridine, the dependent cells become contact-inhibited. The transition to the contact-inhibited state is reversed when bromodeoxyuridine is added back to the medium, if the bromodeoxyuridine is incorporated into dividing cells. The effects of bromodeoxyuridine on growth rate and on contact inhibition are separable.

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Year:  1974        PMID： 4530304      PMCID： PMC433766          DOI： 10.1073/pnas.71.9.3338

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Total substitution of bromodeoxyuridine for thymidine in the DNA of a bromodeoxyuridine-dependent cell line.

Authors:  M D Bick; R L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

3.  "Contact inhibition" of cell division in 3T3 cells.

Authors:  R W Holley; J A Kiernan
Journal:  Proc Natl Acad Sci U S A       Date:  1968-05       Impact factor: 11.205

4.  The initiation of cell division in a contact-inhibited mammalian cell line.

Authors:  G J Todaro; G K Lazar; H Green
Journal:  J Cell Physiol       Date:  1965-12       Impact factor: 6.384

5.  Bromodeoxyuridine dependence--a new mutation in mammalian cells.

Authors:  R L Davidson; M D Bick
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

6.  Suppression of malignancy and differentiation in melanotic melanoma cells.

Authors:  S Silagi; S A Bruce
Journal:  Proc Natl Acad Sci U S A       Date:  1970-05       Impact factor: 11.205
  6 in total
  3 in total

1.  Congenital retroflexion of the penis and inguinal cryptorchidism in a presumptive bovine twin with a 60,XY/60,XX/61,XX,+cen chromosome constitution.

Authors:  W C Hare
Journal:  Can J Comp Med       Date:  1976-10

2.  Bromodeoxyuridine mutagenesis in mammalian cells: mutagenesis is independent of the amount of bromouracil in DNA.

Authors:  E R Kaufman; R L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

3.  Repair and fixation of potentially lethal damage (PLD) as demonstrated by delayed plating or incubation with araA in contact inhibited refed plateau-phase C3H mouse embryo 10 T1/2 cells grown in the presence of BrdUrd.

Authors:  G Iliakis; E Wright; F Q Ngo
Journal:  Radiat Environ Biophys       Date:  1987       Impact factor: 1.925
  3 in total

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