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Literature DB >> 4527822

Growth control in cultured mouse fibroblasts: induction of the pleiotypic and mitogenic responses by a purified growth factor.

P S Rudland, W Seifert, D Gospodarowicz.

Abstract

Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.

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Year: 1974 PMID： 4527822 PMCID： PMC388513 DOI： 10.1073/pnas.71.7.2600

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts.

Authors: J Otten; G S Johnson; I Pastan
Journal: J Biol Chem Date: 1972-11-10 Impact factor: 5.157

2. Difference in the cyclic adenosine 3',5'-monophosphate levels in normal and transformed cells.

Authors: J R Sheppard
Journal: Nat New Biol Date: 1972-03-01

3. Topoinhibition and serum requirement of transformed and untransformed cells.

Authors: R Dulbecco
Journal: Nature Date: 1970-08-22 Impact factor: 49.962

4. Studies on carcinogenesis by avian sarcoma viruses. VI. Differential multiplication of uninfected and of converted cells in response to insulin.

Authors: H M Temin
Journal: J Cell Physiol Date: 1967-06 Impact factor: 6.384

5. "Pleiotypic response".

Authors: A Hershko; P Mamont; R Shields; G M Tomkins
Journal: Nat New Biol Date: 1971-08

6. Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroplasts.

Authors: D Paul; A Lipton; I Klinger
Journal: Proc Natl Acad Sci U S A Date: 1971-03 Impact factor: 11.205

7. "Contact inhibition" of cell division in 3T3 cells.

Authors: R W Holley; J A Kiernan
Journal: Proc Natl Acad Sci U S A Date: 1968-05 Impact factor: 11.205

8. The initiation of cell division in a contact-inhibited mammalian cell line.

Authors: G J Todaro; G K Lazar; H Green
Journal: J Cell Physiol Date: 1965-12 Impact factor: 6.384

9. Detection of polyadenylic acid sequences in viral and eukaryotic RNA(polu(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4).

Authors: R Sheldon; C Jurale; J Kates
Journal: Proc Natl Acad Sci U S A Date: 1972-02 Impact factor: 11.205

10. Insulin receptors in human circulating cells and fibroblasts.

Authors: J R Gavin; J Roth; P Jen; P Freychet
Journal: Proc Natl Acad Sci U S A Date: 1972-03 Impact factor: 11.205

25 in total

1. Induction of growth in resting fibroblastic cell cultures by Ca++.

Authors: R Dulbecco; J Elkington
Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

2. Effect of serum on cells cultured from human mammary tumors.

Authors: E V Gaffney; D Pigott
Journal: In Vitro Date: 1978-05

Review 3. Factors involved in the modulation of cell proliferation in vivo and in vitro: the role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells.

Authors: D Gospodarowicz; G Greenburg; H Bialecki; B R Zetter
Journal: In Vitro Date: 1978-01

Review 4. Fibroblast and epidermal growth factors: their uses in vivo and in vitro in studies on cell functions and cell transplantation.

Authors: D Gospodarowicz
Journal: Mol Cell Biochem Date: 1979-05-21 Impact factor: 3.396

5. Cyclic nucleotides and growth control in cultured mouse cells: correlation of changes in intracellular 3':5' cGMP concentration with a specific phase of the cell cycle.

Authors: W Seifert; P S Rudland
Journal: Proc Natl Acad Sci U S A Date: 1974-12 Impact factor: 11.205

6. Effect of a fibroblast growth factor, insulin, dexamethasone, and serum on the morphology of BALB/c 3T3 cells.

Authors: D Gospodarowicz; J Moran
Journal: Proc Natl Acad Sci U S A Date: 1974-12 Impact factor: 11.205

7. Stimulation of division of sparse and confluent 3T3 cell populations by a fibroblast growth factor, dexamethasone, and insulin.

Authors: D Gospodarowicz; J S Moran
Journal: Proc Natl Acad Sci U S A Date: 1974-11 Impact factor: 11.205