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Literature DB >> 4527605

A common tumour specific antigen. II. Further characterization of the whole antigen and of a cross-reacting antigen of normal tissues.

J P Dickinson, J R McDermott, J K Smith, E A Caspary.

Abstract

Experimental evidence supporting the postulated analogy between myelin basic protein and a previously described common tumour specific antigen is summarized under antigenic cross-reactivity, subcellular localization, molecular size, basicity and proteolipid nature. A third protein antigen, present in all tissues, also shows strong similarities in all these respects.

Entities: Disease Gene

Mesh：

Substances：

Year: 1974 PMID： 4527605 PMCID： PMC2009113 DOI： 10.1038/bjc.1974.94

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

27 in total

1. The protein composition of isolated myelin.

Authors: F Gonzalez-Sastre
Journal: J Neurochem Date: 1970-07 Impact factor: 5.372

2. The homogeneity and protein composition of rat brain myelin.

Authors: D H Adams; M E Fox
Journal: Brain Res Date: 1969-08 Impact factor: 3.252

3. Experimental allergic encephalomyelitis. An encephalitogenic basic protein from bovine myelin.

Authors: E H Eylar; J Salk; G C Beveridge; L V Brown
Journal: Arch Biochem Biophys Date: 1969-06 Impact factor: 4.013

4. Localization of encephalitogenic basic protein in the intraperiod line of lamellar myelin.

Authors: J P Dickinson; K M Jones; S R Aparicio; C E Lumsden
Journal: Nature Date: 1970-09-12 Impact factor: 49.962

5. Purifications and properties of basic proteins in pig spinal cord and peripheral nerve.

Authors: K Uyemura; C Tobari; S Hirano
Journal: Biochim Biophys Acta Date: 1970-07-27

6. Immunologic response to altered encephalitogenic protein in guinea pigs.

Authors: R H Swanborg
Journal: J Immunol Date: 1969-02 Impact factor: 5.422

7. Lymphocyte sensitisation: an in-vitro test for cancer?

Authors: E J Field; E A Caspary
Journal: Lancet Date: 1970-12-26 Impact factor: 79.321

8. A new proteolipid fraction of the nervous system. I. Isolation and amino acid analyses.

Authors: F Wolfgram
Journal: J Neurochem Date: 1966-06 Impact factor: 5.372

9. Comparison of lymphocyte transformation and intradermal reactions to tuberculins.

Authors: W McFarland; D H Heilman
Journal: Am Rev Respir Dis Date: 1966-05

10. Chemical studies on experimental allergic encephalomyelitis. Peptide as the common denominator in all encephalitogenic 'antigens'.

Authors: C E Lumsden; D M Robertson; R Blight
Journal: J Neurochem Date: 1966-03 Impact factor: 5.372

8 in total

4. Tumor-secific immunity to chemically induced tumors. Evidence for immunologic specificity and shared antigenicity in lymphocyte responses to soluble tumor antigens.

Authors: J T Frbes; Y Nakaw; R T Smith
Journal: J Exp Med Date: 1975-05-01 Impact factor: 14.307

A common tumour specific antigen. II. Further characterization of the whole antigen and of a cross-reacting antigen of normal tissues.

1. The protein composition of isolated myelin.

2. The homogeneity and protein composition of rat brain myelin.

3. Experimental allergic encephalomyelitis. An encephalitogenic basic protein from bovine myelin.

4. Localization of encephalitogenic basic protein in the intraperiod line of lamellar myelin.

5. Purifications and properties of basic proteins in pig spinal cord and peripheral nerve.

6. Immunologic response to altered encephalitogenic protein in guinea pigs.

7. Lymphocyte sensitisation: an in-vitro test for cancer?

8. A new proteolipid fraction of the nervous system. I. Isolation and amino acid analyses.

9. Comparison of lymphocyte transformation and intradermal reactions to tuberculins.

10. Chemical studies on experimental allergic encephalomyelitis. Peptide as the common denominator in all encephalitogenic 'antigens'.

Review 1. Human tumour-associated and tumour-specific antigens: some concepts in relation to clinical oncology.

2. Lymphocyte response to antigen stimulation as measured by fluorescence polarization (SCM test).

3. Usefulness of the SCM test in the diagnosis of gastric cancer.

4. Tumor-secific immunity to chemically induced tumors. Evidence for immunologic specificity and shared antigenicity in lymphocyte responses to soluble tumor antigens.

5. Cellular immunity to encephalitogenic peptide in tumour-bearing mice.

6. Tumour antigenicity in ovarian cancer.

7. Responses of cancer patients in the MEM test: not just a function of charge on basic proteins.

8. Measurement by leukocyte adherence inhibition of autosensitization of cancer patients to myelin basic protein.