Literature DB >> 4526220

Prolongation of the life-span in mice adapted to large amounts of L-dopa.

G C Cotzias, S T Miller, A R Nicholson, W H Maston, L C Tang.   

Abstract

Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.

Entities:  

Mesh:

Substances:

Year:  1974        PMID: 4526220      PMCID: PMC388479          DOI: 10.1073/pnas.71.6.2466

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  15 in total

1.  Nutrition and longevity in the rat. I. Food intake in relation to size, health and fertility.

Authors:  B N Berg
Journal:  J Nutr       Date:  1960-07       Impact factor: 4.798

2.  Susceptibility to cold in newborns of levodopa-treated rats.

Authors:  I Mena; G López; K Horiuchi; H Croxatto
Journal:  Nature       Date:  1972-09-29       Impact factor: 49.962

3.  Synthesis of DOPA in rat stomach following ingestion of cereals.

Authors:  R D Hoeldtke; R J Wurtman
Journal:  Metabolism       Date:  1974-01       Impact factor: 8.694

4.  Cereal ingestion and catecholamine excretion.

Authors:  R D Hoeldtke; R J Wurtman
Journal:  Metabolism       Date:  1974-01       Impact factor: 8.694

5.  Block of cerebral actions of L-dopa with methyl receptor substances.

Authors:  G C Cotzias; L Tang; J Z Ginos; A R Nicholson; P S Papavasiliou
Journal:  Nature       Date:  1971-06-25       Impact factor: 49.962

6.  A mutation influencing the transportation of manganese, L-dopa, and L-tryptophan.

Authors:  G C Cotzias; L C Tang; S T Miller; D Sladic-Simic; L S Hurley
Journal:  Science       Date:  1972-04-28       Impact factor: 47.728

7.  An investigation of a new instrument to measure motor activity of small animals.

Authors:  T H Svensson; G Thieme
Journal:  Psychopharmacologia       Date:  1969

8.  Aromatic amino acids and modification of parkinsonism.

Authors:  G C Cotzias; M H Van Woert; L M Schiffer
Journal:  N Engl J Med       Date:  1967-02-16       Impact factor: 91.245

9.  Melatonin and abnormal movements induced by L-dopa in mice.

Authors:  G C Cotzias; L C Tang; S T Miller; J Z Ginos
Journal:  Science       Date:  1971-07-30       Impact factor: 47.728

Review 10.  Metabolic modification of Parkinson's disease and of chronic manganese poisoning.

Authors:  G C Cotzias; P S Papavasiliou; J Ginos; A Steck; S Düby
Journal:  Annu Rev Med       Date:  1971       Impact factor: 13.739

View more
  12 in total

1.  Morphine sulfate stimulates the adenylate cyclase in mouse caudate nuclei.

Authors:  L C Tang; G C Cotzias
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

Review 2.  Carcinogenesis and aging--two related phenomena? A review.

Authors:  H C Pitot
Journal:  Am J Pathol       Date:  1977-05       Impact factor: 4.307

3.  Changing the actions of neuroactive drugs by changing brain protein synthesis.

Authors:  L C Tang; G C Cotzias; M Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

Review 4.  Levodopa in Parkinson's disease: neurotoxicity issue laid to rest?

Authors:  M G Murer; R Raisman-Vozari; O Gershanik
Journal:  Drug Saf       Date:  1999-11       Impact factor: 5.606

Review 5.  Between destiny and disease: genetics and molecular pathways of human central nervous system aging.

Authors:  Christin Glorioso; Etienne Sibille
Journal:  Prog Neurobiol       Date:  2010-12-02       Impact factor: 11.685

6.  Age related changes in blood-to-brain amino acid transport and incorporation into brain protein.

Authors:  S Samuels; I Fish; S A Schwartz; U Hochgeschwender
Journal:  Neurochem Res       Date:  1983-02       Impact factor: 3.996

Review 7.  Dopamine and aging: intersecting facets.

Authors:  C David Rollo
Journal:  Neurochem Res       Date:  2008-10-08       Impact factor: 3.996

8.  L-3,4-dihydroxyphenylalanine-induced hypersensitivity simulating features of denervation.

Authors:  L C Tang; G C Cotzias
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

9.  GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats.

Authors:  Wayne Chadwick; Bronwen Martin; Megan C Chapter; Sung-Soo Park; Liyun Wang; Caitlin M Daimon; Randall Brenneman; Stuart Maudsley
Journal:  PLoS One       Date:  2012-05-14       Impact factor: 3.240

10.  Challenges facing age-management/longevity medicine.

Authors:  Richard F Walker
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.