Literature DB >> 4525300

A neurohypophyseal hormone analog with selective oxytocin-like activities and resistance to enzymatic inactivation: an approach to the design of peptide drugs.

R Walter, T Yamanaka, S Sakakibara.   

Abstract

Stepwise, synthetic alteration of oxytocin, guided by conformational and enzymological considerations, has led to analogs with specifically modified activity profiles and resistance to enzymatic inactivation. General requirements for the design of peptides with therapeutic value are discussed.

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Year:  1974        PMID： 4525300      PMCID： PMC388350          DOI： 10.1073/pnas.71.5.1901

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Comparison of the pharmacologic properties of oxytocin and its highly potent analogue, desamino-oxytocin.

Authors:  W Y CHAN; V DU VIGNEAUD
Journal:  Endocrinology       Date:  1962-12       Impact factor: 4.736

2.  Effect of magnesium ion on the response of the rat uterus to neurohypophysial hormones and analogues.

Authors:  R A MUNSICK
Journal:  Endocrinology       Date:  1960-03       Impact factor: 4.736

3.  Differences in the antidiuretic responses of rats to the intravenous administration of lysine and arginine vasopressins.

Authors:  W H SAWYER
Journal:  Endocrinology       Date:  1958-11       Impact factor: 4.736

4.  Conformation of lysine vasopressin: a comparison with oxytocin.

Authors:  R Walter; J D Glickson; I L Schwartz; R T Havran; J Meienhofer; D W Urry
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

5.  1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties.

Authors:  S Hase; S Sakakibara; M Wahrenburg; M Kirchberger; I L Schwartz; R Walter
Journal:  J Am Chem Soc       Date:  1972-05-17       Impact factor: 15.419

6.  Thiol-protein disulfide oxidoreductase activity in human placental tissue homogenates.

Authors:  L A Branda; B M Ferrier; L Celhoffer
Journal:  Can J Biochem       Date:  1972-05

7.  Inactivation of neurohypophyseal peptides by a uterine enzyme. Characterization of the hydrolytic cleavage.

Authors:  J D Glass; B M Dubois; I L Schwartz; R Walter
Journal:  Endocrinology       Date:  1970-10       Impact factor: 4.736

Review 8.  Evolution of antidiuretic hormones and their functions.

Authors:  W H Sawyer
Journal:  Am J Med       Date:  1967-05       Impact factor: 4.965

9.  A pharmacologic analysis of the significance of the chemical functional groups of oxytocin to its oxytocic activity and on the effect of magnesium on the in vitro and in vivo oxytocic activity of neurohypophysial hormones.

Authors:  W Y Chan; N Kelley
Journal:  J Pharmacol Exp Ther       Date:  1967-04       Impact factor: 4.030

10.  [Identification of 2 new neurohypophyseal hormones, valitocin (val 8 -oxytocin) and aspartocin (asn 4 -oxytocin) in a selachian fish, the spiny dog-fish (Squalus acanthias)].

Authors:  R Acher; J Chauvet; M T Chauvet
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1972-01-10
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  4 in total

1.  Contribution of the peptide backbone to the action of oxytocin analogs.

Authors:  O Hechter; T Kato; S H Nakagawa; F Yang; G Flouret
Journal:  Proc Natl Acad Sci U S A       Date:  1975-02       Impact factor: 11.205

2.  Replication of colicin E1 plasmid DNA in cell extracts. Origin and direction of replication.

Authors:  J Tomizawa; Y Sakakibara; T Kakefuda
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

3.  Designing of peptides with desired half-life in intestine-like environment.

Authors:  Arun Sharma; Deepak Singla; Mamoon Rashid; Gajendra Pal Singh Raghava
Journal:  BMC Bioinformatics       Date:  2014-08-20       Impact factor: 3.169

4.  Clearance of oxytocin and its potentially enzyme resistant analogues in the OXT-receptor compartment of the potassium depolarized rat myometrium.

Authors:  Vladimir Pliska; Guido Jutz
Journal:  J Pept Sci       Date:  2021-10-14       Impact factor: 2.408
  4 in total

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